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Consensus on molecular imaging and theranostics in prostate cancer

Rapid developments in imaging and treatment with radiopharmaceuticals targeting prostate cancer pose issues for the development of guidelines for their appropriate use. To tackle this problem, international experts representing medical oncologists, urologists, radiation oncologists, radiologists, an...

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Main Authors: Fanti, Stefano (Author) , Minozzi, Silvia (Author) , Antoch, Gerald (Author) , Banks, Ian (Author) , Briganti, Alberto (Author) , Carrio, Ignasi (Author) , Chiti, Arturo (Author) , Clarke, Noel (Author) , Eiber, Matthias (Author) , De Bono, Johann (Author) , Fizazi, Karim (Author) , Gillessen, Silke (Author) , Gledhill, Sam (Author) , Haberkorn, Uwe (Author) , Herrmann, Ken (Author) , Hicks, Rodney J (Author) , Lecouvet, Frederic (Author) , Montironi, Rodolfo (Author) , Ost, Piet (Author) , O'Sullivan, Joe M (Author) , Padhani, Anwar R (Author) , Schalken, Jack A (Author) , Scher, Howard I (Author) , Tombal, Bertrand (Author) , van Moorselaar, R Jeroen A (Author) , Van Poppel, Heindrik (Author) , Vargas, Hebert Alberto (Author) , Walz, Jochen (Author) , Weber, Wolfgang A (Author) , Wester, Hans-Jürgen (Author) , Oyen, Wim J G (Author)
Format: Article (Journal)
Language:English
Published: 28 November 2018
In: The lancet. Oncology
Year: 2018, Volume: 19, Issue: 12, Pages: e696-e708
ISSN:1474-5488
DOI:10.1016/S1470-2045(18)30604-1
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S1470-2045(18)30604-1
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1470204518306041
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Author Notes:Stefano Fanti, Silvia Minozzi, Gerald Antoch, Ian Banks, Alberto Briganti, Ignasi Carrio, Arturo Chiti, Noel Clarke, Matthias Eiber, Johann De Bono, Karim Fizazi, Silke Gillessen, Sam Gledhill, Uwe Haberkorn, Ken Herrmann, Rodney J Hicks, Frederic Lecouvet, Rodolfo Montironi, Piet Ost, Joe M O'Sullivan, Anwar R Padhani, Jack A Schalken, Howard I Scher, Bertrand Tombal, R Jeroen A van Moorselaar, Heindrik Van Poppel, Hebert Alberto Vargas, Jochen Walz, Wolfgang A Weber, Hans-Jürgen Wester, Wim J G Oyen
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Summary:Rapid developments in imaging and treatment with radiopharmaceuticals targeting prostate cancer pose issues for the development of guidelines for their appropriate use. To tackle this problem, international experts representing medical oncologists, urologists, radiation oncologists, radiologists, and nuclear medicine specialists convened at the European Association of Nuclear Medicine Focus 1 meeting to deliver a balanced perspective on available data and clinical experience of imaging in prostate cancer, which had been supported by a systematic review of the literature and a modified Delphi process. Relevant conclusions included the following: diphosphonate bone scanning and contrast-enhanced CT are mentioned but rarely recommended for most patients in clinical guidelines; MRI (whole-body or multiparametric) and prostate cancer-targeted PET are frequently suggested, but the specific contexts in which these methods affect practice are not established; sodium fluoride-18 for PET-CT bone scanning is not widely advocated, whereas gallium-68 or fluorine-18 prostate-specific membrane antigen gain acceptance; and, palliative treatment with bone targeting radiopharmaceuticals (rhenium-186, samarium-153, or strontium-89) have largely been replaced by radium-223 on the basis of the survival benefit that was reported in prospective trials, and by other systemic therapies with proven survival benefits. Although the advances in MRI and PET-CT have improved the accuracy of imaging, the effects of these new methods on clinical outcomes remains to be established. Improved communication between imagers and clinicians and more multidisciplinary input in clinical trial design are essential to encourage imaging insights into clinical decision making.
Item Description:Gesehen am 21.04.2020
Physical Description:Online Resource
ISSN:1474-5488
DOI:10.1016/S1470-2045(18)30604-1

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