Pharmacological decrease of liver stiffness is pressure-related and predicts long-term clinical outcome
Liver stiffness (LS) as measured by transient elastography is increasingly used to noninvasively assess liver fibrosis. However, LS is efficiently modulated by confounders like arterial and portal pressure (PP). We here study the effect of acute hemodynamic changes on LS (measured by µFibroscan) in...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
18 September 2018
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| In: |
American journal of physiology. Gastrointestinal and liver physiology
Year: 2018, Volume: 315, Issue: 4, Pages: G484-G494 |
| ISSN: | 1522-1547 |
| DOI: | 10.1152/ajpgi.00392.2017 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1152/ajpgi.00392.2017 Verlag, lizenzpflichtig, Volltext: https://journals.physiology.org/doi/full/10.1152/ajpgi.00392.2017 
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| Author Notes: | Felix Piecha, Mattias Mandorfer, Teresa Peccerella, Ann-Kathrin Ozga, Tanja Poth, Anna Vonbank, Helmut Karl Seitz, Vanessa Rausch, Thomas Reiberger, and Sebastian Mueller |
| Summary: | Liver stiffness (LS) as measured by transient elastography is increasingly used to noninvasively assess liver fibrosis. However, LS is efficiently modulated by confounders like arterial and portal pressure (PP). We here study the effect of acute hemodynamic changes on LS (measured by µFibroscan) in a rodent model of cirrhosis in response to pharmacological modulation of PP by losartan, nitric oxide donors, and propranolol. |
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| Item Description: | Gesehen am 21.04.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1522-1547 |
| DOI: | 10.1152/ajpgi.00392.2017 |