Pro-neuronal activity of Myod1 due to promiscuous binding to neuronal genes

Lee, Mall et al. explore why the sequence-related transcription factors Myod1 and Ascl1 lead to different reprogramming outcomes when expressed in fibroblasts, despite binding similar targets.

Saved in:

Bibliographic Details
Main Authors:	Lee, Qian Yi (Author) , Mall, Moritz (Author) , Chanda, Soham (Author) , Zhou, Bo (Author) , Sharma, Kylesh S. (Author) , Schaukowitch, Katie (Author) , Adrián Segarra, Juan Manuel (Author) , Grieder, Sarah D. (Author) , Kareta, Michael S. (Author) , Wapinski, Orly L. (Author) , Ang, Cheen Euong (Author) , Li, Rui (Author) , Südhof, Thomas C. (Author) , Chang, Howard Y. (Author) , Wernig, Marius (Author)
Format:	Article (Journal)
Language:	English
Published:	[April 2020]
In:	Nature cell biology Year: 2020, Volume: 22, Issue: 4, Pages: 401-411
ISSN:	1476-4679
DOI:	10.1038/s41556-020-0490-3
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41556-020-0490-3 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41556-020-0490-3
Author Notes:	Qian Yi Lee, Moritz Mall, Soham Chanda, Bo Zhou, Kylesh S. Sharma, Katie Schaukowitch, Juan M. Adrian-Segarra, Sarah D. Grieder, Michael S. Kareta, Orly L. Wapinski, Cheen Euong Ang, Rui Li, Thomas C. Südhof, Howard Y. Chang, Marius Wernig

Description
Summary:	Lee, Mall et al. explore why the sequence-related transcription factors Myod1 and Ascl1 lead to different reprogramming outcomes when expressed in fibroblasts, despite binding similar targets.
Item Description:	Gesehen am 21.04.2020
Physical Description:	Online Resource
ISSN:	1476-4679
DOI:	10.1038/s41556-020-0490-3