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Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications

Molecular mechanisms leading to the adaptation of breast cancer (BC) cells to hypoxia are largely unknown. The anti-apoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) is frequently amplified in BC; and elevated Mcl-1 levels have been correlated with poor prognosis. Here we investigated th...

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Main Authors: Bashari, Muhammad Hasan (Author) , Fan, Fengjuan (Author) , Vallet, Sonia (Author) , Sattler, Martin (Author) , Arn, Melissa (Author) , Luckner-Minden, Claudia (Author) , Schulze-Bergkamen, Henning (Author) , Zörnig, Inka (Author) , Marmé, Frederik (Author) , Schneeweiss, Andreas (Author) , Cardone, Michael H. (Author) , Opferman, Joseph T. (Author) , Jäger, Dirk (Author) , Podar, Klaus (Author)
Format: Article (Journal)
Language:English
Published: 26 February 2016
In: Breast cancer research
Year: 2016, Volume: 18, Pages: 1-15
ISSN:1465-542X
DOI:10.1186/s13058-016-0686-4
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13058-016-0686-4
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Author Notes:Muhammad Hasan Bashari, Fengjuan Fan, Sonia Vallet, Martin Sattler, Melissa Arn, Claudia Luckner-Minden, Henning Schulze-Bergkamen, Inka Zörnig, Frederik Marme, Andreas Schneeweiss, Michael H. Cardone, Joseph T. Opferman, Dirk Jäger, and Klaus Podar
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Summary:Molecular mechanisms leading to the adaptation of breast cancer (BC) cells to hypoxia are largely unknown. The anti-apoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) is frequently amplified in BC; and elevated Mcl-1 levels have been correlated with poor prognosis. Here we investigated the pathophysiologic role of Mcl-1 in Her2-positive BC cells under hypoxic conditions.
Item Description:Gesehen am 22.04.2020
Physical Description:Online Resource
ISSN:1465-542X
DOI:10.1186/s13058-016-0686-4

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