Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications
Molecular mechanisms leading to the adaptation of breast cancer (BC) cells to hypoxia are largely unknown. The anti-apoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) is frequently amplified in BC; and elevated Mcl-1 levels have been correlated with poor prognosis. Here we investigated th...
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| Hauptverfasser: | , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
26 February 2016
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| In: |
Breast cancer research
Year: 2016, Jahrgang: 18, Pages: 1-15 |
| ISSN: | 1465-542X |
| DOI: | 10.1186/s13058-016-0686-4 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13058-016-0686-4 |
| Verfasserangaben: | Muhammad Hasan Bashari, Fengjuan Fan, Sonia Vallet, Martin Sattler, Melissa Arn, Claudia Luckner-Minden, Henning Schulze-Bergkamen, Inka Zörnig, Frederik Marme, Andreas Schneeweiss, Michael H. Cardone, Joseph T. Opferman, Dirk Jäger, and Klaus Podar |
| Zusammenfassung: | Molecular mechanisms leading to the adaptation of breast cancer (BC) cells to hypoxia are largely unknown. The anti-apoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) is frequently amplified in BC; and elevated Mcl-1 levels have been correlated with poor prognosis. Here we investigated the pathophysiologic role of Mcl-1 in Her2-positive BC cells under hypoxic conditions. |
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| Beschreibung: | Gesehen am 22.04.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 1465-542X |
| DOI: | 10.1186/s13058-016-0686-4 |