2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations

Nonsense mutations can be corrected by several molecules that activate readthrough of premature termination codon. Here, the authors report that 2,6-diaminopurine efficiently corrects UGA nonsense mutations with no significant toxicity.

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Bibliographic Details
Main Authors:	Trzaska, Carole (Author) , Amand, Séverine (Author) , Bailly, Christine (Author) , Leroy, Catherine (Author) , Marchand, Virginie (Author) , Duvernois-Berthet, Evelyne (Author) , Saliou, Jean-Michel (Author) , Benhabiles, Hana (Author) , Werkmeister, Elisabeth (Author) , Chassat, Thierry (Author) , Guilbert, Romain (Author) , Hannebique, David (Author) , Mouray, Anthony (Author) , Copin, Marie-Christine (Author) , Moreau, Pierre-Arthur (Author) , Adriaenssens, Eric (Author) , Kulozik, Andreas (Author) , Westhof, Eric (Author) , Tulasne, David (Author) , Motorin, Yuri (Author) , Rebuffat, Sylvie (Author) , Lejeune, Fabrice (Author)
Format:	Article (Journal)
Language:	English
Published:	[2020]
In:	Nature Communications Year: 2020, Volume: 11
ISSN:	2041-1723
DOI:	10.1038/s41467-020-15140-z
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-020-15140-z Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-020-15140-z
Author Notes:	Carole Trzaska, Séverine Amand, Christine Bailly, Catherine Leroy, Virginie Marchand, Evelyne Duvernois-Berthet, Jean-Michel Saliou, Hana Benhabiles, Elisabeth Werkmeister, Thierry Chassat, Romain Guilbert, David Hannebique, Anthony Mouray, Marie-Christine Copin, Pierre-Arthur Moreau, Eric Adriaenssens, Andreas Kulozik, Eric Westhof, David Tulasne, Yuri Motorin, Sylvie Rebuffat, Fabrice Lejeune

Description
Summary:	Nonsense mutations can be corrected by several molecules that activate readthrough of premature termination codon. Here, the authors report that 2,6-diaminopurine efficiently corrects UGA nonsense mutations with no significant toxicity.
Item Description:	Gesehen am 23.04.2020
Physical Description:	Online Resource
ISSN:	2041-1723
DOI:	10.1038/s41467-020-15140-z