Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Leukaemic stem cells in acute myeloid leukaemia are defined by a lack of expression of NKG2D ligands, which mediates their ability to evade surveillance by NK cells.

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Bibliographic Details
Main Authors:	Paczulla, Anna Maria (Author) , Raffel, Simon (Author) , Nievergall, Eva (Author) , Lutz, Christoph (Author) , Trumpp, Andreas (Author)
Format:	Article (Journal) Editorial
Language:	English
Published:	17 July 2019
In:	Nature Year: 2019, Volume: 572, Issue: 7768, Pages: 254–259
ISSN:	1476-4687
DOI:	10.1038/s41586-019-1410-1
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41586-019-1410-1 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41586-019-1410-1
Author Notes:	Anna M. Paczulla, Kathrin Rothfelder, Simon Raffel, Martina Konantz, Julia Steinbacher, Hui Wang, Claudia Tandler, Marcelle Mbarga, Thorsten Schaefer, Mattia Falcone, Eva Nievergall, Daniela Dörfel, Pauline Hanns, Jakob R. Passweg, Christoph Lutz, Juerg Schwaller, Robert Zeiser, Bruce R. Blazar, Michael A. Caligiuri, Stephan Dirnhofer, Pontus Lundberg, Lothar Kanz, Leticia Quintanilla-Martinez, Alexander Steinle, Andreas Trumpp, Helmut R. Salih & Claudia Lengerke

Description
Summary:	Leukaemic stem cells in acute myeloid leukaemia are defined by a lack of expression of NKG2D ligands, which mediates their ability to evade surveillance by NK cells.
Item Description:	Nach Seite 259 folgen weitere 27 Seiten Gesehen am 23.04.2020
Physical Description:	Online Resource
ISSN:	1476-4687
DOI:	10.1038/s41586-019-1410-1