Prognostic significance of cell cycle-associated proteins p16, pRB, cyclin D1 and p53 in resected oropharyngeal carcinoma
Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) has an improved outcome and may allow for treatment de-escalation. High-risk HPV (HR-HPV) infection is associated with deregulated expression of the cell cycle-associated proteins p16INK4, pRB, cyclin D1 and p53. The ob...
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
06 September 2018
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| In: |
Journal of otolaryngology, head & neck surgery
Year: 2018, Jahrgang: 47 |
| ISSN: | 1916-0216 |
| DOI: | 10.1186/s40463-018-0298-3 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s40463-018-0298-3
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| Verfasserangaben: | Michaela Plath, Martina A. Broglie, Diana Förbs, Sandro J. Stoeckli and Wolfram Jochum |
| Zusammenfassung: | Human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) has an improved outcome and may allow for treatment de-escalation. High-risk HPV (HR-HPV) infection is associated with deregulated expression of the cell cycle-associated proteins p16INK4, pRB, cyclin D1 and p53. The objective of this study was to assess cell cycle proteins as potential surrogate markers for HR-HPV DNA testing to identify OPSCC with favorable prognosis after resection. |
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| Beschreibung: | Gesehen am 23.04.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 1916-0216 |
| DOI: | 10.1186/s40463-018-0298-3 |