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IL-10 inducible CD8+ regulatory T-cells are enriched in patients with multiple myeloma and impact the generation of antigen-specific T-cells

Tumor-mediated immunosuppression via regulatory T-cells is a key player among the various immune-escape mechanisms in multiple myeloma. We analyzed the generation, distribution, function and immunophenotype of CD8+CD28− regulatory T-cells in patients with multiple myeloma. Functionality of CD8+CD28−...

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Main Authors: Plaumann, Julian (Author) , Engelhardt, Melanie (Author) , Awwad, Mohamed (Author) , Raab, Marc-Steffen (Author) , Hillengaß, Jens (Author) , Halama, Niels (Author) , Neuber, Brigitte (Author) , Müller-Tidow, Carsten (Author) , Goldschmidt, Hartmut (Author) , Hundemer, Michael (Author)
Format: Article (Journal)
Language:English
Published: 20 August 2018
In: Cancer immunology immunotherapy
Year: 2018, Volume: 67, Issue: 11, Pages: 1695-1707
ISSN:1432-0851
DOI:10.1007/s00262-018-2230-0
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00262-018-2230-0
Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007/s00262-018-2230-0
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Author Notes:Julian Plaumann, Melanie Engelhardt, Mohamed H. S. Awwad, Hakim Echchannaoui, Eva Amman, Marc S. Raab, Jens Hillengass, Niels Halama, Brigitte Neuber, Carsten Müller-Tidow, Hartmut Goldschmidt, Michael Hundemer
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Summary:Tumor-mediated immunosuppression via regulatory T-cells is a key player among the various immune-escape mechanisms in multiple myeloma. We analyzed the generation, distribution, function and immunophenotype of CD8+CD28− regulatory T-cells in patients with multiple myeloma. Functionality of CD8+CD28− T-cells was assessed by immunological assays using ex vivo generated antigen-specific T-cells from patients with plasma cell dyscrasias and healthy donors. Detailed analysis of distribution, immunophenotype and cytotoxic potential of CD8+CD28− T-cells was performed by flow cytometry and ELISA.
Item Description:Im Titel ist das Pluszeichen bei "CB8" hochgestellt
Gesehen am 23.04.2020
Physical Description:Online Resource
ISSN:1432-0851
DOI:10.1007/s00262-018-2230-0

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