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Adverse drug reactions associated with amitriptyline - protocol for a systematic multiple-indication review and meta-analysis

Unwanted anticholinergic effects are both underestimated and frequently overlooked. Failure to identify adverse drug reactions (ADRs) can lead to prescribing cascades and the unnecessary use of over-the-counter products. The objective of this systematic review and meta-analysis is to explore and qua...

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Main Authors: Brückle, Maria-Sophie (Author) , Thomas, Elizabeth T. (Author) , Seide, Svenja (Author) , Pilz, Maximilian (Author) , González-González, Ana I. (Author) , Dinh, Truc Sophia (Author) , Harder, Sebastian (Author) , Glasziou, Paul (Author) , Gerlach, Ferdinand M. (Author) , Muth, Christiane (Author)
Format: Article (Journal)
Language:English
Published: 17 March 2020
In: Systematic Reviews
Year: 2020, Volume: 9
ISSN:2046-4053
DOI:10.1186/s13643-020-01296-8
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13643-020-01296-8
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Author Notes:Maria-Sophie Brueckle, Elizabeth T. Thomas, Svenja E. Seide, Maximilian Pilz, Ana Isabel Gonzalez-Gonzalez, Truc Sophia Nguyen, Sebastian Harder, Paul P. Glasziou, Ferdinand M. Gerlach and Christiane Muth
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Summary:Unwanted anticholinergic effects are both underestimated and frequently overlooked. Failure to identify adverse drug reactions (ADRs) can lead to prescribing cascades and the unnecessary use of over-the-counter products. The objective of this systematic review and meta-analysis is to explore and quantify the frequency and severity of ADRs associated with amitriptyline vs. placebo in randomized controlled trials (RCTs) involving adults with any indication, as well as healthy individuals.
Item Description:Gesehen am 23.04.2020
Physical Description:Online Resource
ISSN:2046-4053
DOI:10.1186/s13643-020-01296-8

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