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mTORC1 and PKB/Akt control the muscle response to denervation by regulating autophagy and HDAC4

Denervation leads to muscle atrophy and neuromuscular endplate remodeling. Here, the authors show that a balanced activation of mTORC1 contributes to the dynamic regulation of autophagic flux in denervated muscle and that activation of PKB/Akt promotes the nuclear import of HDAC4, which is essential...

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Main Authors: Castets, Perrine (Author) , Rion, Nathalie (Author) , Théodore, Marine (Author) , Falcetta, Denis (Author) , Lin, Shuo (Author) , Reischl, Markus (Author) , Wild, Franziska (Author) , Guérard, Laurent (Author) , Eickhorst, Christopher (Author) , Brockhoff, Marielle (Author) , Guridi, Maitea (Author) , Ibebunjo, Chikwendu (Author) , Cruz, Joseph (Author) , Sinnreich, Michael (Author) , Rudolf, Rüdiger (Author) , Glass, David J. (Author) , Rüegg, Markus A. (Author)
Format: Article (Journal)
Language:English
Published: 18 July 2019
In: Nature Communications
Year: 2019, Volume: 10, Pages: 16
ISSN:2041-1723
DOI:10.1038/s41467-019-11227-4
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-019-11227-4
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-019-11227-4
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Author Notes:Perrine Castets, Nathalie Rion, Marine Théodore, Denis Falcetta, Shuo Lin, Markus Reischl, Franziska Wild, Laurent Guérard, Christopher Eickhorst, Marielle Brockhoff, Maitea Guridi, Chikwendu Ibebunjo, Joseph Cruz, Michael Sinnreich, Rüdiger Rudolf, David J. Glass & Markus A. Rüegg
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Summary:Denervation leads to muscle atrophy and neuromuscular endplate remodeling. Here, the authors show that a balanced activation of mTORC1 contributes to the dynamic regulation of autophagic flux in denervated muscle and that activation of PKB/Akt promotes the nuclear import of HDAC4, which is essential for endplate maintenance upon nerve injury
Item Description:Gesehen am 24.04.2020
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-019-11227-4

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