High-throughput discovery of cancer-targeting TCRs: [chapter 20]
The high-throughput discovery of T cell receptors (TCR) enables us to follow the longitudinal course of tumor disease, to monitor immunotherapy-related repertoire alterations, and exploit TCRs for therapeutic use. Here we discuss state of the art and future experimental and computational strategies...
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| Main Authors: | , , |
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| Format: | Chapter/Article |
| Language: | English |
| Published: |
6 November 2019
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| In: |
Tumor Immunology and immunotherapy
Year: 2019, Pages: 401-417 |
| DOI: | 10.1016/bs.mie.2019.10.009 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0076687919304112 Verlag: https://doi.org/10.1016/bs.mie.2019.10.009 
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| Author Notes: | Lukas Bunse, Edward W. Green, Michael Platten |
| Summary: | The high-throughput discovery of T cell receptors (TCR) enables us to follow the longitudinal course of tumor disease, to monitor immunotherapy-related repertoire alterations, and exploit TCRs for therapeutic use. Here we discuss state of the art and future experimental and computational strategies to dissect the hypervariable world of TCRs and their corresponding antigens in the context of cancer immunotherapy. |
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| Item Description: | Gesehen am 28.04.2020 |
| Physical Description: | Online Resource |
| DOI: | 10.1016/bs.mie.2019.10.009 |