Autotaxin upregulated by STAT3 activation contributes to invasion in pancreatic neuroendocrine neoplasms
Although the upregulation of autotaxin (ATX) is associated with many solid tumours, its role in pancreatic neuroendocrine neoplasms (pNEN) has not been well elucidated. The expression of ATX in pNEN tissues and pNEN cell line BON1 was analysed by Western blot, PCR and immunocytochemistry upon exposu...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
10 October 2018
|
| In: |
Endocrine Connections
Year: 2018, Volume: 7, Issue: 12, Pages: 1299-1307 |
| ISSN: | 2049-3614 |
| DOI: | 10.1530/EC-18-0356 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1530/EC-18-0356 Verlag, lizenzpflichtig, Volltext: https://ec.bioscientifica.com/view/journals/ec/7/12/EC-18-0356.xml 
|
| Author Notes: | Linfei Yang, Xiao Yu and Yongchao Yang |
| Summary: | Although the upregulation of autotaxin (ATX) is associated with many solid tumours, its role in pancreatic neuroendocrine neoplasms (pNEN) has not been well elucidated. The expression of ATX in pNEN tissues and pNEN cell line BON1 was analysed by Western blot, PCR and immunocytochemistry upon exposure to interleukin-6 (IL-6). Additionally, pNEN cell line BON1 was transfected with siRNAs against ATX or signal transducer and activator of transcription 3 (STAT3) and assessed by in vitro invasion assays. |
|---|---|
| Item Description: | Gesehen am 28.04.2020 |
| Physical Description: | Online Resource |
| ISSN: | 2049-3614 |
| DOI: | 10.1530/EC-18-0356 |