Estrogen-related receptors and the control of bone cell fate
Bone loss is naturally occurring in aging males and females and exacerbated in the latter after menopause, altogether leading to cumulative skeleton fragility and increased fracture risk. Two types of therapeutic strategies can be envisioned to counteract age- or menopause-associated bone loss, aimi...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2016
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| In: |
Molecular and cellular endocrinology
Year: 2015, Volume: 432, Pages: 37-43 |
| ISSN: | 1872-8057 |
| DOI: | 10.1016/j.mce.2015.07.019 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.mce.2015.07.019 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0303720715300265 
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| Author Notes: | Julie Carnesecchi, Jean-Marc Vanacker |
| Summary: | Bone loss is naturally occurring in aging males and females and exacerbated in the latter after menopause, altogether leading to cumulative skeleton fragility and increased fracture risk. Two types of therapeutic strategies can be envisioned to counteract age- or menopause-associated bone loss, aiming at either reducing bone resorption exerted by osteoclasts or, alternatively, promoting bone formation by osteoblasts. We here summarize data suggesting that inhibition of the Estrogen-Related Receptors α and/or γ could promote bone formation and compensate for bone loss induced by ageing or estrogen-deficiency. |
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| Item Description: | Available online 20 July 2015 Gesehen am 29.04.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1872-8057 |
| DOI: | 10.1016/j.mce.2015.07.019 |