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Human cytomegalovirus glycoprotein B inhibits migration of breast cancer MDA‑MB‑231 cells and impairs TGF‑β/Smad2/3 expression

Breast cancer is a leading cause of cancer‑associated mortality in females worldwide and evidence suggests that human cytomegalovirus (HCMV) infection may be implicated in the progress of breast cancer. HCMV glycoprotein B (gB) is the most abundant envelope protein and serves an important role in ho...

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Main Authors: Yang, Rui (Author) , Liang, Jie (Author) , Xu, Guo-Xiong (Author) , Ding, Liu-Mei (Author) , Huang, Hong-Mei (Author) , Su, Qi-Zhu (Author) , Yan, Jing (Author) , Li, Yun-Chun (Author)
Format: Article (Journal)
Language:English
Published: March 23, 2018
In: Oncology letters
Year: 2018, Volume: 15, Issue: 5, Pages: 7730-7738
ISSN:1792-1082
DOI:10.3892/ol.2018.8344
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.3892/ol.2018.8344
Verlag, lizenzpflichtig, Volltext: http://www.spandidos-publications.com/10.3892/ol.2018.8344/abstract
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Author Notes:Rui Yang, Jie Liang, Guo-Xiong Xu, Liu-Mei Ding, Hong-Mei Huang, Qi-Zhu Su, Jing Yan and Yun-Chun Li
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Summary:Breast cancer is a leading cause of cancer‑associated mortality in females worldwide and evidence suggests that human cytomegalovirus (HCMV) infection may be implicated in the progress of breast cancer. HCMV glycoprotein B (gB) is the most abundant envelope protein and serves an important role in host cell entry. The present study aimed to clarify the role of HCMV gB in breast cancer cells.
Item Description:Gesehen am 29.04.2020
Physical Description:Online Resource
ISSN:1792-1082
DOI:10.3892/ol.2018.8344

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