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Effect of the number of pregnancies on mortality risk in HIV-infected women: a prospective cohort study in rural KwaZulu-Natal, South Africa

We investigated whether mortality risk increases with the number of full-term pregnancies in HIV-infected women. Our study is based on data from the ACDIS cohort, collected in rural KwaZulu-Natal, South Africa. Mortality risk for different number of pregnancies in HIV-infected women was analyzed usi...

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Bibliographic Details
Main Authors: Yoo, Hyunsuk (Author) , Bärnighausen, Till (Author)
Format: Article (Journal)
Language:English
Published: 02 August 2018
In: Aids and behavior
Year: 2018, Volume: 22, Issue: 12, Pages: 3971-3980
ISSN:1573-3254
DOI:10.1007/s10461-018-2232-0
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s10461-018-2232-0
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Author Notes:Hyunsuk Yoo, Juyeon Lee, Jae-Joon Yim, Till Bärnighausen, Frank Tanser, Sue K. Park
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Summary:We investigated whether mortality risk increases with the number of full-term pregnancies in HIV-infected women. Our study is based on data from the ACDIS cohort, collected in rural KwaZulu-Natal, South Africa. Mortality risk for different number of pregnancies in HIV-infected women was analyzed using Cox proportional hazards model. The risk of TB or AIDS mortality in HIV-uninfected women did not change with the number of full-term pregnancies, while the corresponding risk increased markedly in HIV-infected women. The risk of TB or AIDS mortality increased 1.48-fold (95% CI 1.25-1.75), 1.76-fold (95% CI 1.45-2.13), and 1.59-fold (95% CI 1.31-1.94) for one, two, and three or more full-term pregnancies compared to none, respectively. Finally, women who are young (age < 26) have greater risk of TB or AIDS mortality compared to women who are old (age ≥ 26), and women residing in rural areas have greater risk compared to women who reside in non-rural areas.
Item Description:Gesehen am 29.04.2020
Physical Description:Online Resource
ISSN:1573-3254
DOI:10.1007/s10461-018-2232-0

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