Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4

Cancer cells rely on dysregulated gene expression. This establishes specific transcriptional addictions that may be therapeutically exploited. Yet, the mechanisms that are ultimately responsible for these addictions are poorly understood. Here, we investigated the transcriptional dependencies of tra...

Full description

Bibliographic Details

Main Authors:	Zanconato, Francesca (Author) , Battilana, Giusy (Author) , Forcato, Mattia (Author) , Filippi, Letizia (Author) , Azzolin, Luca (Author) , Manfrin, Andrea (Author) , Quaranta, Erika (Author) , Biagio, Daniele Di (Author) , Sigismondo, Gianluca (Author) , Guzzardo, Vincenza (Author) , Lejeune, Pascale (Author) , Haendler, Bernard (Author) , Krijgsveld, Jeroen (Author) , Fassan, Matteo (Author) , Bicciato, Silvio (Author) , Cordenonsi, Michelangelo (Author) , Piccolo, Stefano (Author)
Format:	Article (Journal)
Language:	English
Published:	17 September 2018
In:	Nature medicine Year: 2018, Volume: 24, Issue: 10, Pages: 1599-1610
ISSN:	1546-170X
DOI:	10.1038/s41591-018-0158-8
Online Access:	Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41591-018-0158-8 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41591-018-0158-8
Author Notes:	Francesca Zanconato, Giusy Battilana, Mattia Forcato, Letizia Filippi, Luca Azzolin, Andrea Manfrin, Erika Quaranta, Daniele Di Biagio, Gianluca Sigismondo, Vincenza Guzzardo, Pascale Lejeune, Bernard Haendler, Jeroen Krijgsveld, Matteo Fassan, Silvio Bicciato, Michelangelo Cordenonsi and Stefano Piccolo