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Golgi stress mediates redox imbalance and ferroptosis in human cells

Hamed Alborzinia et al. show that Golgi-dispersing compounds trigger iron-dependent oxidative degradation of lipids, inducing a non-apoptotic cell death called ferroptosis. This study provides insight into the role of Golgi apparatus for preventing ferroptotic cell death through its cellular redox c...

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Main Authors: Alborzinia, Hamed (Author) , Ignashkova, Tatiana I. (Author) , Dejure, Francesca Romana (Author) , Gendarme, Mathieu (Author) , Theobald, Jannick (Author) , Wölfl, Stefan (Author) , Lindemann, Ralph K. (Author) , Reiling, Jan H. (Author)
Format: Article (Journal)
Language:English
Published: 28 November 2018
In: Communications biology
Year: 2018, Volume: 1, Pages: 1-15
ISSN:2399-3642
DOI:10.1038/s42003-018-0212-6
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s42003-018-0212-6
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s42003-018-0212-6
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Author Notes:Hamed Alborzinia, Tatiana I. Ignashkova, Francesca R. Dejure, Mathieu Gendarme, Jannick Theobald, Stefan Wölfl, Ralph K. Lindemann & Jan H. Reiling
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Summary:Hamed Alborzinia et al. show that Golgi-dispersing compounds trigger iron-dependent oxidative degradation of lipids, inducing a non-apoptotic cell death called ferroptosis. This study provides insight into the role of Golgi apparatus for preventing ferroptotic cell death through its cellular redox control.
Item Description:Gesehen am 30.04.2020
Physical Description:Online Resource
ISSN:2399-3642
DOI:10.1038/s42003-018-0212-6

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