Golgi stress mediates redox imbalance and ferroptosis in human cells
Hamed Alborzinia et al. show that Golgi-dispersing compounds trigger iron-dependent oxidative degradation of lipids, inducing a non-apoptotic cell death called ferroptosis. This study provides insight into the role of Golgi apparatus for preventing ferroptotic cell death through its cellular redox c...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
28 November 2018
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| In: |
Communications biology
Year: 2018, Jahrgang: 1, Pages: 1-15 |
| ISSN: | 2399-3642 |
| DOI: | 10.1038/s42003-018-0212-6 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s42003-018-0212-6 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s42003-018-0212-6 |
| Verfasserangaben: | Hamed Alborzinia, Tatiana I. Ignashkova, Francesca R. Dejure, Mathieu Gendarme, Jannick Theobald, Stefan Wölfl, Ralph K. Lindemann & Jan H. Reiling |
| Zusammenfassung: | Hamed Alborzinia et al. show that Golgi-dispersing compounds trigger iron-dependent oxidative degradation of lipids, inducing a non-apoptotic cell death called ferroptosis. This study provides insight into the role of Golgi apparatus for preventing ferroptotic cell death through its cellular redox control. |
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| Beschreibung: | Gesehen am 30.04.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 2399-3642 |
| DOI: | 10.1038/s42003-018-0212-6 |