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Methylome-based cell-of-origin modeling (Methyl-COOM) identifies aberrant expression of immune regulatory molecules in CLL

In cancer, normal epigenetic patterns are disturbed and contribute to gene expression changes, disease onset, and progression. The cancer epigenome is composed of the epigenetic patterns present in the tumor-initiating cell at the time of transformation, and the tumor-specific epigenetic alterations...

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Main Authors: Wierzbińska, Justyna Anna (Author) , Toth, Reka (Author) , Ishaque, Naveed (Author) , Rippe, Karsten (Author) , Mallm, Jan-Philipp (Author) , Klett, Lara C. (Author) , Mertens, Daniel (Author) , Zenz, Thorsten (Author) , Hielscher, Thomas (Author) , Seifert, Marc (Author) , Küppers, Ralf (Author) , Assenov, Yassen (Author) , Lutsik, Pavlo (Author) , Stilgenbauer, Stephan (Author) , Rößner, Philipp M. (Author) , Seiffert, Martina (Author) , Byrd, John (Author) , Oakes, Christopher C. (Author) , Plass, Christoph (Author) , Lipka, Daniel (Author)
Format: Article (Journal)
Language:English
Published: 18 March 2020
In: Genome medicine
Year: 2020, Volume: 12, Pages: 1-19
ISSN:1756-994X
DOI:10.1186/s13073-020-00724-7
Online Access:Verlag, kostenfrei: https://doi.org/10.1186/s13073-020-00724-7
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Author Notes:Justyna A. Wierzbinska, Reka Toth, Naveed Ishaque, Karsten Rippe, Jan-Philipp Mallm, Lara C. Klett, Daniel Mertens, Thorsten Zenz, Thomas Hielscher, Marc Seifert, Ralf Küppers, Yassen Assenov, Pavlo Lutsik, Stephan Stilgenbauer, Philipp M. Roessner, Martina Seiffert, John Byrd, Christopher C. Oakes, Christoph Plass and Daniel B. Lipka
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Summary:In cancer, normal epigenetic patterns are disturbed and contribute to gene expression changes, disease onset, and progression. The cancer epigenome is composed of the epigenetic patterns present in the tumor-initiating cell at the time of transformation, and the tumor-specific epigenetic alterations that are acquired during tumor initiation and progression. The precise dissection of these two components of the tumor epigenome will facilitate a better understanding of the biological mechanisms underlying malignant transformation. Chronic lymphocytic leukemia (CLL) originates from differentiating B cells, which undergo extensive epigenetic programming. This poses the challenge to precisely determine the epigenomic ground state of the cell-of-origin in order to identify CLL-specific epigenetic aberrations.
Item Description:Gesehen am 30.04.2020
Physical Description:Online Resource
ISSN:1756-994X
DOI:10.1186/s13073-020-00724-7

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