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Preoperative serum thymidine kinase activity as novel monitoring, prognostic, and predictive biomarker in pancreatic cancer

Objective: The aim of the study was to investigate serum thymidine kinase 1 (S-TK) activity as a diagnostic and prognostic marker for patients with pancreatic ductal adenocarcinoma (PDAC). Methods: Using the sensitive TK activity assay DiviTum, preoperative serum samples from 404 PDAC, 28 chronic pa...

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Main Authors: Felix, Klaus M. (Author) , Hinz, Ulf (Author) , Dobiasch, Sophie (Author) , Hackert, Thilo (Author) , Bergmann, Frank (Author) , Neumüller, Magnus (Author) , Gronowitz, Simon (Author) , Bergqvist, Mattias (Author) , Strobel, Oliver (Author)
Format: Article (Journal)
Language:English
Published: 2018
In: Pancreas
Year: 2017, Volume: 47, Issue: 1, Pages: 72-79
ISSN:1536-4828
DOI:10.1097/MPA.0000000000000966
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/MPA.0000000000000966
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/pancreasjournal/Fulltext/2018/01000/Preoperative_Serum_Thymidine_Kinase_Activity_as.11.aspx
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Author Notes:Klaus Felix, PhD, Ulf Hinz, MSc, Sophie Dobiasch, MD, Thilo Hackert, MD, Frank Bergmann, MD, Magnus Neumüller, PhD, Simon Gronowitz, PhD, Mattias Bergqvist, BSc, and Oliver Strobel, MD
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Summary:Objective: The aim of the study was to investigate serum thymidine kinase 1 (S-TK) activity as a diagnostic and prognostic marker for patients with pancreatic ductal adenocarcinoma (PDAC). Methods: Using the sensitive TK activity assay DiviTum, preoperative serum samples from 404 PDAC, 28 chronic pancreatitis, and 25 autoimmune pancreatitis patients and 83 healthy volunteers were analyzed. The preoperative S-TK activities of 54 PDAC patients who received neoadjuvant therapy (nTx) were also compared with those of 258 PDAC patients who did not receive nTx. Results: The preoperative S-TK activities of PDAC patients were significantly higher and discriminatory from autoimmune and chronic pancreatitis patients and control groups. The S-TK activity in PDAC patients was associated with overall survival. Patients with S-TK activity of less than 80 Du (DiviTum units)/L demonstrated median survival of 20.3 months with an estimated 18.0% 5-year survival rate; for S-TK activity of 80 Du/L or greater, median survival was 15.1 months with a 6.8% 5-year survival rate. For early-stage PDAC, these differences were even more pronounced. The S-TK activity in the nTx group was significantly higher than that in the group not receiving nTx. Conclusions: Pancreatic ductal adenocarcinomas reveal a significant increase in S-TK activity, which is associated with overall survival, especially in early tumor stages. Serum thymidine kinase 1 activity may be a useful parameter for monitoring nTx efficacy.
Item Description:Accepted October 17, 2017
Gesehen am 04.05.2020
Physical Description:Online Resource
ISSN:1536-4828
DOI:10.1097/MPA.0000000000000966

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