Preoperative serum thymidine kinase activity as novel monitoring, prognostic, and predictive biomarker in pancreatic cancer
Objective: The aim of the study was to investigate serum thymidine kinase 1 (S-TK) activity as a diagnostic and prognostic marker for patients with pancreatic ductal adenocarcinoma (PDAC). Methods: Using the sensitive TK activity assay DiviTum, preoperative serum samples from 404 PDAC, 28 chronic pa...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2018
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| In: |
Pancreas
Year: 2017, Volume: 47, Issue: 1, Pages: 72-79 |
| ISSN: | 1536-4828 |
| DOI: | 10.1097/MPA.0000000000000966 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/MPA.0000000000000966 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/pancreasjournal/Fulltext/2018/01000/Preoperative_Serum_Thymidine_Kinase_Activity_as.11.aspx 
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| Author Notes: | Klaus Felix, PhD, Ulf Hinz, MSc, Sophie Dobiasch, MD, Thilo Hackert, MD, Frank Bergmann, MD, Magnus Neumüller, PhD, Simon Gronowitz, PhD, Mattias Bergqvist, BSc, and Oliver Strobel, MD |
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| 245 | 1 | 0 | |a Preoperative serum thymidine kinase activity as novel monitoring, prognostic, and predictive biomarker in pancreatic cancer |c Klaus Felix, PhD, Ulf Hinz, MSc, Sophie Dobiasch, MD, Thilo Hackert, MD, Frank Bergmann, MD, Magnus Neumüller, PhD, Simon Gronowitz, PhD, Mattias Bergqvist, BSc, and Oliver Strobel, MD |
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| 520 | |a Objective: The aim of the study was to investigate serum thymidine kinase 1 (S-TK) activity as a diagnostic and prognostic marker for patients with pancreatic ductal adenocarcinoma (PDAC). Methods: Using the sensitive TK activity assay DiviTum, preoperative serum samples from 404 PDAC, 28 chronic pancreatitis, and 25 autoimmune pancreatitis patients and 83 healthy volunteers were analyzed. The preoperative S-TK activities of 54 PDAC patients who received neoadjuvant therapy (nTx) were also compared with those of 258 PDAC patients who did not receive nTx. Results: The preoperative S-TK activities of PDAC patients were significantly higher and discriminatory from autoimmune and chronic pancreatitis patients and control groups. The S-TK activity in PDAC patients was associated with overall survival. Patients with S-TK activity of less than 80 Du (DiviTum units)/L demonstrated median survival of 20.3 months with an estimated 18.0% 5-year survival rate; for S-TK activity of 80 Du/L or greater, median survival was 15.1 months with a 6.8% 5-year survival rate. For early-stage PDAC, these differences were even more pronounced. The S-TK activity in the nTx group was significantly higher than that in the group not receiving nTx. Conclusions: Pancreatic ductal adenocarcinomas reveal a significant increase in S-TK activity, which is associated with overall survival, especially in early tumor stages. Serum thymidine kinase 1 activity may be a useful parameter for monitoring nTx efficacy. | ||
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