Resting vagal activity in schizophrenia: meta-analysis of heart rate variability as a potential endophenotype
Background - Cardiac vagal tone, indexed by heart rate variability (HRV), is a proxy - for the functional integrity of feedback mechanisms integrating central - and peripheral physiology. Aims - To quantify differences in HRV in individuals with schizophrenia compared - with healthy controls. Method...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2016
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| In: |
The British journal of psychiatry
Year: 2015, Jahrgang: 208, Heft: 1, Pages: 9-16 |
| ISSN: | 1472-1465 |
| DOI: | 10.1192/bjp.bp.114.160762 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1192/bjp.bp.114.160762 Verlag, lizenzpflichtig, Volltext: https://www.cambridge.org/core/journals/the-british-journal-of-psychiatry/article/resting-vagal-activity-in-schizophrenia-metaanalysis-of-heart-rate-variability-as-a-potential-endophenotype/7A76D9F7D23BD889E7CA39A98CE42A66 
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| Verfasserangaben: | Annika Clamor, Tania M. Lincoln, Julian F. Thayer and Julian Koenig |
| Zusammenfassung: | Background - Cardiac vagal tone, indexed by heart rate variability (HRV), is a proxy - for the functional integrity of feedback mechanisms integrating central - and peripheral physiology. Aims - To quantify differences in HRV in individuals with schizophrenia compared - with healthy controls. Method - Databases were systematically searched for studies eligible for - inclusion. Random effect meta-analyses of standardised mean differences - were calculated for vagal activity indicated by high-frequency HRV and - the root mean square of successive R-R interval differences (RMSSD). Results - Thirty-four studies were included. Significant main effects were found - for high-frequency HRV (P = 0.0008; Hedges' - g =-0.98, 95% CI −1.56 to −0.41, k = - 29) and RMSSD (P<0.0001; g =-0.91, - 95% CI −1.19 to −0.62, k = 24), indicating lower vagal - activity in individuals with schizophrenia than in healthy controls. - Considerable heterogeneity was evident but effects were robust in - subsequent sensitivity analyses. Conclusions - Given the association between low HRV, threat processing, emotion - regulation and executive functioning, reduced vagal tone may be an - endophenotype for the development of psychotic symptoms. |
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| Beschreibung: | accepted 19 Feb 2015 Gesehen am 04.05.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 1472-1465 |
| DOI: | 10.1192/bjp.bp.114.160762 |