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Podoplanin as key player of tumor progression and lymph vessel proliferation in ovarian cancer

Background/Aim: Podoplanin plays a key role in tumor progression and metastasis. We evaluated lymphatics proliferation rate and podoplanin expression in tumor cells of ovarian carcinoma. Materials and Methods: Seventy-five paraffin-embedded specimens of ovarian cancer were immunohistochemically asse...

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Hauptverfasser: Cobec, Ionut Marcel (VerfasserIn) , Sas, Ioan (VerfasserIn) , Pirtea, Laurențiu (VerfasserIn) , Cimpean, Anca Maria (VerfasserIn) , Moatar, Aurica Elisabeta (VerfasserIn) , Ceaușu, Raluca Amalia (VerfasserIn) , Raica, Marius (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: September 20, 2016
In: Anticancer research
Year: 2016, Jahrgang: 36, Heft: 10, Pages: 5265-5272
ISSN:1791-7530
Online-Zugang:Verlag, lizenzpflichtig, Volltext: http://ar.iiarjournals.org/content/36/10/5265
Volltext
Verfasserangaben:Ionut Marcel Cobec, Ioan Sas, Laurențiu Pirtea, Anca Maria Cimpean, Aurica Elisabeta Moatar, Raluca Amalia Ceaușu and Marius Raica
Beschreibung
Zusammenfassung:Background/Aim: Podoplanin plays a key role in tumor progression and metastasis. We evaluated lymphatics proliferation rate and podoplanin expression in tumor cells of ovarian carcinoma. Materials and Methods: Seventy-five paraffin-embedded specimens of ovarian cancer were immunohistochemically assessed in order to quantify peritumoral (LMVDP) and intratumoral (LMVDT) lymphatic microvessel density of proliferating lymphatics and for podoplanin variability in tumor cells. Results and Conclusion: LMVDT correlated with proliferating tumor vessels located in the peritumoral area (p=0.024) and with the number of mature vessels located in the intratumoral area (p<0.0001), while LMVDP correlated with peritumoral mature vessels (p<0.000l). Proliferating tumor cells at the invasive front were highly positive for podoplanin. To the best of our knowledge, this study represents the first assessment of lymphatic endothelial cell proliferation correlated with podoplanin expression in tumor cells from ovarian cancer. Our data support podoplanin as a potential target that may help reduce ovarian cancer dissemination and lymphatic metastasis.
Beschreibung:Gesehen am 04.05.2020
Beschreibung:Online Resource
ISSN:1791-7530

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