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Activation of myenteric glia during acute inflammation in vitro and in vivo

Enteric glial cells (EGCs) are the main constituent of the enteric nervous system and share similarities with astrocytes from the central nervous system including their reactivity to an inflammatory microenvironment. Previous studies on EGC pathophysiology have specifically focused on mucosal glia a...

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Main Authors: Rosenbaum, Corinna (Author) , Schick, Martin (Author) , Wollborn, Jakob (Author) , Heider, Andreas (Author) , Scholz, Claus Jürgen (Author) , Cecil, Alexander (Author) , Niesler, Beate (Author) , Hirrlinger, Johannes (Author) , Walles, Heike (Author) , Metzger, Marco (Author)
Format: Article (Journal)
Language:English
Published: March 10, 2016
In: PLOS ONE
Year: 2016, Volume: 11, Issue: 3
ISSN:1932-6203
DOI:10.1371/journal.pone.0151335
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.pone.0151335
Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151335
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Author Notes:Corinna Rosenbaum, Martin Alexander Schick, Jakob Wollborn, Andreas Heider, Claus-Jürgen Scholz, Alexander Cecil, Beate Niesler, Johannes Hirrlinger, Heike Walles, Marco Metzger
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Summary:Enteric glial cells (EGCs) are the main constituent of the enteric nervous system and share similarities with astrocytes from the central nervous system including their reactivity to an inflammatory microenvironment. Previous studies on EGC pathophysiology have specifically focused on mucosal glia activation and its contribution to mucosal inflammatory processes observed in the gut of inflammatory bowel disease (IBD) patients. In contrast knowledge is scarce on intestinal inflammation not locally restricted to the mucosa but systemically affecting the intestine and its effect on the overall EGC network.
Item Description:Gesehen am 05.05.2020
Physical Description:Online Resource
ISSN:1932-6203
DOI:10.1371/journal.pone.0151335

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