Solid phase synthesis of C-terminal boronic acid peptides
Peptides and peptidomimetics with a C-terminal boronic acid group have prolific applications in numerous fields of research, but their synthetic accessibility remains problematic. A convenient, high yield synthesis of peptide-boronic acids on a solid support is described here, using commercially ava...
Gespeichert in:
| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
April 22, 2016
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| In: |
Organic letters
Year: 2016, Jahrgang: 18, Heft: 9, Pages: 2016-2019 |
| ISSN: | 1523-7052 |
| DOI: | 10.1021/acs.orglett.6b00625 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/acs.orglett.6b00625
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| Verfasserangaben: | Mira A. M. Behnam, Tom R. Sundermann, and Christian D. Klein |
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| 520 | |a Peptides and peptidomimetics with a C-terminal boronic acid group have prolific applications in numerous fields of research, but their synthetic accessibility remains problematic. A convenient, high yield synthesis of peptide-boronic acids on a solid support is described here, using commercially available 1-glycerol polystyrene resin. The method is compatible with Fmoc chemistry and offers a versatile approach to aryl and alkyl aminoboronic acids without additional purification steps. | ||
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