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Urinary fibrogenic cytokines ET-1 and TGF-β1 are associated with urinary angiotensinogen levels in obese children

Fibrogenic cytokines are recognized as putative drivers of disease activity and histopathological deterioration in various kidney diseases. We compared urinary transforming growth factor β1 (U-TGF-β1) and endothelin 1 (U-ET-1) levels across body mass index classes and assessed their association with...

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Main Authors: Correia-Costa, Liane (Author) , Morato, Manuela (Author) , Sousa, Teresa (Author) , Cosme, Dina (Author) , Guimarães, João Tiago (Author) , Guerra, António (Author) , Schaefer, Franz (Author) , Afonso, Alberto Caldas (Author) , Azevedo, Ana (Author) , Albino-Teixeira, António (Author)
Format: Article (Journal)
Language:English
Published: 2016
In: Pediatric nephrology
Year: 2015, Volume: 31, Issue: 3, Pages: 455-464
ISSN:1432-198X
DOI:10.1007/s00467-015-3232-1
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00467-015-3232-1
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Author Notes:Liane Correia-Costa, Manuela Morato, Teresa Sousa, Dina Cosme, João Tiago Guimarães, António Guerra, Franz Schaefer, Alberto Caldas Afonso, Ana Azevedo and António Albino-Teixeira
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Summary:Fibrogenic cytokines are recognized as putative drivers of disease activity and histopathological deterioration in various kidney diseases. We compared urinary transforming growth factor β1 (U-TGF-β1) and endothelin 1 (U-ET-1) levels across body mass index classes and assessed their association with the level of urinary angiotensinogen (U-AGT), a biomarker of intrarenal renin-angiotensin-aldosterone system (RAAS).
Item Description:Published: 19 October 2015
Gesehen am 05.05.2020
Physical Description:Online Resource
ISSN:1432-198X
DOI:10.1007/s00467-015-3232-1

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