Cover Image

Lysophosphatidic acids and autotaxin in retinal vein occlusion

Purpose: - To analyze the levels of lysophosphatidic acids (LPAs) and autotaxin (ATX) in undiluted vitreous of untreated patients with retinal vein occlusion (RVO). - Methods: - Sixty-four vitreous samples (40 RVO, 24 controls with idiopathic floaters) were analyzed in this retrospective case seri...

Full description

Saved in:
Bibliographic Details
Main Authors: Steliyanova Dacheva, Ivanka (Author) , Ullmer, Christoph (Author) , Ceglowska, Karolina (Author) , Nogoceke, Everson (Author) , Hartmann, Guido (Author) , Müller, Stephan (Author) , Rejdak, Robert (Author) , Nowomiejska, Katarzyna (Author) , Reich, Michael (Author) , Nobl, Matthias Johannes (Author) , Tandogan, Tamer (Author) , Kretz, Florian Tobias Alwin (Author) , Auffarth, Gerd U. (Author) , Koss, Michael Janusz (Author)
Format: Article (Journal)
Language:English
Published: July 2016
In: Retina
Year: 2016, Volume: 36, Issue: 12, Pages: 2311-2318
ISSN:1539-2864
DOI:10.1097/IAE.0000000000001112
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/IAE.0000000000001112
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/retinajournal/Abstract/2016/12000/LYSOPHOSPHATIDIC_ACIDS_AND_AUTOTAXIN_IN_RETINAL.9.aspx
Get full text
Author Notes:Dacheva, Ivanka; Ullmer, Christoph PhD; Ceglowska, Karolina; Nogoceke, Everson PhD; Hartmann, Guido PhD; Müller, Stephan PhD; Rejdak, Robert Prof. MD; Nowomiejska, Katarzyna MD; Reich, Michael; Nobl, Matthias; Tandogan, Tamer MD; Kretz, Florian T.A. MD; Auffarth, Gerd U. Prof MD; Koss, Michael J. Prof MD
Description
Summary:Purpose: - To analyze the levels of lysophosphatidic acids (LPAs) and autotaxin (ATX) in undiluted vitreous of untreated patients with retinal vein occlusion (RVO). - Methods: - Sixty-four vitreous samples (40 RVO, 24 controls with idiopathic floaters) were analyzed in this retrospective case series using LC/MS for LPAs 16:0, 18:0, 18:1, 20:4, and ELISA kits or Luminex technology for ATX, angiopoetin-1 (ANG-1), interleukin-6 (IL-6), interleukin-7 (IL-7), interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1), pigment epithelium-derived factor (PEDF), and vascular endothelial growth factor (VEGF). LPA and ATX levels were correlated with the visual acuity, central macular thickness (CMT), average retinal thickness (AvT), vitreal cytokine levels and with each other. - Results: - Levels of every LPA species tested and ATX were significantly increased in the vitreous fluid from all patients with RVO (total LPAs: 968.0 ± 842.3 nM; ATX: 2.5 ± 1.02 nM) compared with controls (total LPAs: 225.2 ± 292.8 nM, P < 0.0001; ATX: 1.9 ± 1.00 nM, P = 0.005). There were strong positive correlations between the vitreal levels of IL-6, IL-8, MCP-1, VEGF and LPAs. - Conclusion: - Levels of LPAs and ATX were positively correlated with proinflammatory cytokines and VEGF and might thus play an important role in the development of macular edema secondary to RVO.
Item Description:Gesehen am 06.05.2020
Physical Description:Online Resource
ISSN:1539-2864
DOI:10.1097/IAE.0000000000001112

Similar Items