Clinical relevance of preformed IgG and IgM antibodies against donor endothelial progenitor cells in recipients of living donor kidney grafts
Background Literature reports suggest that non-HLA-antibodies against human endothelial progenitor cells (EPC) can be detected in pre-transplant recipient serum and that EPC antibodies can have a deleterious influence on the graft. Methods We investigated 71 renal transplant recipients from living d...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2016
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| In: |
Clinical transplantation
Year: 2015, Volume: 30, Issue: 2, Pages: 124-130 |
| ISSN: | 1399-0012 |
| DOI: | 10.1111/ctr.12665 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/ctr.12665 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ctr.12665 
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| Author Notes: | Volker Daniel, Mahmoud Sadeghi, Caner Suesal, Sabine Scherer, Hien Tran, Petra Gombos, Karina Trojan, Christian Morath, Gerhard Opelz |
| Summary: | Background Literature reports suggest that non-HLA-antibodies against human endothelial progenitor cells (EPC) can be detected in pre-transplant recipient serum and that EPC antibodies can have a deleterious influence on the graft. Methods We investigated 71 renal transplant recipients from living donors for a possible influence of pre-transplant donor-specific IgG and/or IgM recipient antibodies against EPC of the donor using the flow cytometric XM-ONE cross-match. Results Eight of the 71 patients developed acute biopsy-proven rejection. Two of these patients showed IgM antibodies against EPC prior to transplantation while the other six patients had neither IgG nor IgM EPC antibodies. Conversely, pre-transplant IgG or IgM antibodies against EPC were detected in 19 patients without acute rejection (3 × both IgG and IgM, 1 × IgG and 15 × IgM). The remaining 44 patients had neither EPC antibodies nor experienced rejection. Comparing serum creatinine levels at one month and one yr post-transplant within and among the three patient groups revealed that serum creatinine levels were similar in patients with or without EPC antibodies (p > 0.05). Conclusion In this series of 71 recipients with living donor kidneys, pre-transplant EPC antibodies detected with the XM-ONE test kit were neither associated with acute rejection nor with graft function at one month or one yr. |
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| Item Description: | First published: 05 November 2015 Gesehen am 06.05.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1399-0012 |
| DOI: | 10.1111/ctr.12665 |