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MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation

The circadian clock and the cell cycle systems coordinate global physiology. Here the authors show that MYC represses the clock genes, together with MIZ1, and induces proliferation, suggesting that MYC inversely modulates cell cycle and circadian clock genes.

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Bibliographic Details
Main Authors: Shostak, Anton (Author) , Ruppert, Bianca (Author) , Ha, Nati (Author) , Bruns, Philipp (Author) , Toprak, Umut (Author) , Eils, Roland (Author) , Schlesner, Matthias (Author) , Diernfellner, Axel (Author) , Brunner, Michael (Author)
Format: Article (Journal)
Language:English
Published: 24 June 2016
In: Nature Communications
Year: 2016, Volume: 7
ISSN:2041-1723
DOI:10.1038/ncomms11807
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/ncomms11807
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/ncomms11807
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Author Notes:Anton Shostak, Bianca Ruppert, Nati Ha, Philipp Bruns, Umut H. Toprak, ICGC MMML-Seq project, Roland Eils, Matthias Schlesner, Axel Diernfellner & Michael Brunner
Description
Summary:The circadian clock and the cell cycle systems coordinate global physiology. Here the authors show that MYC represses the clock genes, together with MIZ1, and induces proliferation, suggesting that MYC inversely modulates cell cycle and circadian clock genes.
Item Description:Gesehen am 24.06.2020
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/ncomms11807

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