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Spatial transcriptome analysis reveals Notch pathway-associated prognostic markers in IDH1 wild-type glioblastoma involving the subventricular zone

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The spatial relationship of glioblastoma (GBM) to the subventricular zone (SVZ) is associated with inferior patient survival. However, the underlying molecular phenotype is largely unknown. We interrogated an SVZ-dependent transcriptome and potential location-specific prognostic markers.

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Main Authors: Jungk, Christine (Author) , Mock, Andreas (Author) , Exner, Janina (Author) , Geisenberger, Christoph (Author) , Warta, Rolf (Author) , Capper, David (Author) , Abdollahi, Amir (Author) , Friauf, Sara (Author) , Lahrmann, Bernd (Author) , Grabe, Niels (Author) , Beckhove, Philipp (Author) , Deimling, Andreas von (Author) , Unterberg, Andreas (Author) , Herold-Mende, Christel (Author)
Format: Article (Journal)
Language:English
Published: [2016]
In: BMC medicine
Year: 2016, Volume: 14
ISSN:1741-7015
DOI:10.1186/s12916-016-0710-7
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12916-016-0710-7
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Author Notes:Christine Jungk, Andreas Mock, Janina Exner, Christoph Geisenberger, Rolf Warta, David Capper, Amir Abdollahi, Sara Friauf, Bernd Lahrmann, Niels Grabe, Philipp Beckhove, Andreas von Deimling, Andreas Unterberg, Christel Herold-Mende
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Summary:The spatial relationship of glioblastoma (GBM) to the subventricular zone (SVZ) is associated with inferior patient survival. However, the underlying molecular phenotype is largely unknown. We interrogated an SVZ-dependent transcriptome and potential location-specific prognostic markers.
Item Description:Gesehen am 06.05.2020
Physical Description:Online Resource
ISSN:1741-7015
DOI:10.1186/s12916-016-0710-7

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