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Mitochondrial uncouplers inhibit clathrin-mediated endocytosis largely through cytoplasmic acidification

Plant cells maintain strict proton gradients over different membranes. Here, Dejonghe et al. show that several protonophores, including the known tyrosine kinase inhibitor TyrphostinA23, inhibit clathrin-mediated endocytosis by disturbing these gradients and causing cytoplasmic acidification.

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Main Authors: Dejonghe, Wim (Author) , Kuenen, Sabine (Author) , Mylle, Evelien (Author) , Vasileva, Mina (Author) , Keech, Olivier (Author) , Viotti, Corrado (Author) , Swerts, Jef (Author) , Fendrych, Matyáš (Author) , Ortiz-Morea, Fausto Andres (Author) , Mishev, Kiril (Author) , Delang, Simon (Author) , Scholl, Stefan (Author) , Zarza, Xavier (Author) , Heilmann, Mareike (Author) , Kourelis, Jiorgos (Author) , Kasprowicz, Jaroslaw (Author) , Nguyen, Le Son Long (Author) , Drozdzecki, Andrzej (Author) , Houtte, Isabelle van (Author) , Szatmári, Anna-Mária (Author) , Majda, Mateusz (Author) , Baisa, Gary (Author) , Bednarek, Sebastian York (Author) , Robert, Stéphanie (Author) , Audenaert, Dominique (Author) , Testerink, Christa (Author) , Munnik, Teun (Author) , Damme, Daniël van (Author) , Heilmann, Ingo (Author) , Schumacher, Karin (Author) , Winne, Johan (Author) , Friml, Jirí (Author) , Verstreken, Patrik (Author) , Russinova, Eugenia (Author)
Format: Article (Journal)
Language:English
Published: 8 June 2016
In: Nature Communications
Year: 2016, Volume: 7, Pages: 1-12
ISSN:2041-1723
DOI:10.1038/ncomms11710
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/ncomms11710
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/ncomms11710
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Author Notes:Wim Dejonghe, Sabine Kuenen, Evelien Mylle, Mina Vasileva, Olivier Keech, Corrado Viotti, Jef Swerts, Matyáš Fendrych, Fausto Andres Ortiz-Morea, Kiril Mishev, Simon Delang, Stefan Scholl, Xavier Zarza, Mareike Heilmann, Jiorgos Kourelis, Jaroslaw Kasprowicz, Le Son Long Nguyen, Andrzej Drozdzecki, Isabelle Van Houtte, Anna-Mária Szatmári, Mateusz Majda, Gary Baisa, Sebastian York Bednarek, Stéphanie Robert, Dominique Audenaert, Christa Testerink, Teun Munnik, Daniël Van Damme, Ingo Heilmann, Karin Schumacher, Johan Winne, Jiří Friml, Patrik Verstreken & Eugenia Russinova
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Summary:Plant cells maintain strict proton gradients over different membranes. Here, Dejonghe et al. show that several protonophores, including the known tyrosine kinase inhibitor TyrphostinA23, inhibit clathrin-mediated endocytosis by disturbing these gradients and causing cytoplasmic acidification.
Item Description:Gesehen am 07.05.2020
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/ncomms11710

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