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Region-specific differences in amyloid precursor protein expression in the mouse hippocampus

The physiological role of amyloid precursor protein (APP) has been extensively investigated in the rodent hippocampus. Evidence suggests that APP plays a role in synaptic plasticity, dendritic and spine morphogenesis, neuroprotection and - at the behavioral level - hippocampus-dependent forms of lea...

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Main Authors: Del Turco, Domenico (Author) , Paul, Mandy H. (Author) , Schlaudraff, Jessica (Author) , Hick, Meike (Author) , Endres, Kristina (Author) , Müller, Ulrike C. (Author) , Deller, Thomas (Author)
Format: Article (Journal)
Language:English
Published: 29 November 2016
In: Frontiers in molecular neuroscience
Year: 2016, Volume: 9
ISSN:1662-5099
DOI:10.3389/fnmol.2016.00134
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fnmol.2016.00134
Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fnmol.2016.00134/full
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Author Notes:Domenico Del Turco, Mandy H. Paul, Jessica Schlaudraff, Meike Hick, Kristina Endres, Ulrike C. Müller and Thomas Deller
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Summary:The physiological role of amyloid precursor protein (APP) has been extensively investigated in the rodent hippocampus. Evidence suggests that APP plays a role in synaptic plasticity, dendritic and spine morphogenesis, neuroprotection and - at the behavioral level - hippocampus-dependent forms of learning and memory. Intriguingly, however, studies focusing on the role of APP in synaptic plasticity have reported diverging results and considerable differences in effect size between the dentate gyrus and area CA1 of the mouse hippocampus. We speculated that regional differences in APP expression could underlie these discrepancies and studied the expression of APP in both regions using immunostaining, in situ hybridization, and laser microdissection in combination with quantitative reverse transcription PCR and western blotting. In sum, our results show that APP is approximately 1.7-fold higher expressed in pyramidal cells of Ammon´s horn than in granule cells of the dentate gyrus. This regional difference in APP expression may explain why loss-of-function approaches using APP-deficient mice revealed a role for APP in Hebbian plasticity in area CA1, whereas this could not be shown in the dentate gyrus of the same APP mutants.
Item Description:Gesehen am 07.05.2020
Physical Description:Online Resource
ISSN:1662-5099
DOI:10.3389/fnmol.2016.00134

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