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Loss of periostin results in impaired regeneration and pancreatic atrophy after cerulein-induced pancreatitis

The extracellular matrix molecule periostin (POSTN, encoded by POSTN), which is secreted by activated pancreatic stellate cells, has important functions in chronic pancreatitis and pancreatic cancer. However, the role of POSTN in acute pancreatitis and subsequent regeneration processes has not been...

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Main Authors: Hausmann, Simone (Author) , Regel, Ivonne (Author) , Steiger, Katja (Author) , Wagner, Nadine (Author) , Thorwirth, Manja (Author) , Schlitter, Anna M. (Author) , Esposito, Irene (Author) , Michalski, Christoph (Author) , Friess, Helmut (Author) , Kleeff, Jörg H. (Author) , Erkan, Mert (Author)
Format: Article (Journal)
Language:English
Published: 2016
In: The American journal of pathology
Year: 2015, Volume: 186, Issue: 1, Pages: 24-31
ISSN:1525-2191
DOI:10.1016/j.ajpath.2015.09.022
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ajpath.2015.09.022
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0002944015006008
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Author Notes:Simone Hausmann, Ivonne Regel, Katja Steiger, Nadine Wagner, Manja Thorwirth, Anna M. Schlitter, Irene Esposito, Christoph W. Michalski, Helmut Friess, Jörg Kleeff, Mert Erkan
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Summary:The extracellular matrix molecule periostin (POSTN, encoded by POSTN), which is secreted by activated pancreatic stellate cells, has important functions in chronic pancreatitis and pancreatic cancer. However, the role of POSTN in acute pancreatitis and subsequent regeneration processes has not been addressed so far. We analyzed the function of POSTN in pancreatic exocrine regeneration after the induction of a severe acute pancreatitis. Postn-deficient mice and wild-type control animals received repetitive cerulein injections, and a detailed histologic analysis of pancreatic tissues was performed. Although there was no difference in pancreatitis severity in the acute inflammatory phase, the recovery of the exocrine pancreas was massively impaired in Postn-deficient mice. Loss of Postn expression was accompanied by strong pancreatic atrophy and acinar-to-adipocyte differentiation, which was also reflected in gene expression patterns. Our data suggest that POSTN is a crucial factor for proper exocrine lineage-specific regeneration after severe acute pancreatitis.
Item Description:Available online 27 November 2015
Gesehen am 07.05.2020
Physical Description:Online Resource
ISSN:1525-2191
DOI:10.1016/j.ajpath.2015.09.022

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