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Synaptic plasticity in area CA1 of rat hippocampal slices following intraventricular application of albumin

Epileptogenesis following insults to the brain may be triggered by a dysfunctional blood-brain barrier (BBB) associated with albumin extravasation and activation of astrocytes. Using ex vivo recordings from the BBB-disrupted hippocampus after neocortical photothrombotic stroke, we previously demonst...

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Main Authors: Salar, Seda (Author) , Lapilover, Ezequiel (Author) , Müller, Julia (Author) , Hollnagel, Jan-Oliver (Author) , Lippmann, Kristina (Author) , Friedman, Alon (Author) , Heinemann, Uwe (Author)
Format: Article (Journal)
Language:English
Published: 10 March 2016
In: Neurobiology of disease
Year: 2016, Volume: 91, Pages: 155-165
ISSN:1095-953X
DOI:10.1016/j.nbd.2016.03.008
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.nbd.2016.03.008
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0969996116300523
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Author Notes:Seda Salar, Ezequiel Lapilover, Julia Müller, Jan-Oliver Hollnagel, Kristina Lippmann, Alon Friedman, Uwe Heinemann
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Summary:Epileptogenesis following insults to the brain may be triggered by a dysfunctional blood-brain barrier (BBB) associated with albumin extravasation and activation of astrocytes. Using ex vivo recordings from the BBB-disrupted hippocampus after neocortical photothrombotic stroke, we previously demonstrated abnormal activity-dependent accumulation of extracellular potassium with facilitated generation of seizure like events and spreading depolarizations. Similar changes could be observed after intracerebroventricular (icv) application of albumin. We hypothesized that alterations in extracellular potassium and glutamate homeostasis might lead to alterations in synaptic interactions. We therefore assessed the effects of icv albumin on homo- and heterosynaptic plasticity in hippocampal CA1, 24h after a single injection or 7days after continuous infusion of icv albumin. We demonstrate alterations in both homo- and heterosynaptic plasticity compared to control conditions in ex vivo slice studies.
Item Description:Gesehen am 07.05.2020
Physical Description:Online Resource
ISSN:1095-953X
DOI:10.1016/j.nbd.2016.03.008

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