Cover Image

Structural evolution of the emerging 2014-2015 GII.17 noroviruses

Recent reports suggest that human genogroup II genotype 17 (GII.17) noroviruses are increasing in prevalence. We analyzed the evolutionary changes of three GII.17 capsid protruding (P) domains. We found that the GII.17 P domains had little cross-reactivity with antisera raised against the dominant G...

Full description

Saved in:
Bibliographic Details
Main Authors: Singh, Bishal (Author) , Koromyslova, Anna D. (Author) , Hefele, Lisa (Author) , Gürth, Clara (Author) , Hansman, Grant S. (Author)
Format: Article (Journal)
Language:English
Published: February 11, 2016
In: Journal of virology
Year: 2016, Volume: 90, Issue: 5, Pages: 2710-2715
ISSN:1098-5514
DOI:10.1128/JVI.03119-15
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1128/JVI.03119-15
Verlag, lizenzpflichtig, Volltext: https://jvi.asm.org/content/90/5/2710
Get full text
Author Notes:Bishal Kumar Singh, Anna Koromyslova, Lisa Hefele, Clara Gürth, Grant S. Hansman
Description
Summary:Recent reports suggest that human genogroup II genotype 17 (GII.17) noroviruses are increasing in prevalence. We analyzed the evolutionary changes of three GII.17 capsid protruding (P) domains. We found that the GII.17 P domains had little cross-reactivity with antisera raised against the dominant GII.4 strains. X-ray structural analysis of GII.17 P domains from 2002 to 2014 and 2015 suggested that surface-exposed substitutions on the uppermost part of the P domain might have generated a novel 2014-2015 GII.17 variant.
Item Description:Gesehen am 08.05.2020
Physical Description:Online Resource
ISSN:1098-5514
DOI:10.1128/JVI.03119-15

Similar Items