Biliary calprotectin, lactoferrin and dimeric pyruvate kinase after liver transplantation are associated with biliary damage and graft survival in a case-control study
Background - After liver transplantation (LT), biliary complications are associated with reduced graft survival. We tested inflammation markers for their association with biliary damage and graft loss in bile. - Material and methods - The study design was a retrospective case-control study. Calprote...
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| Main Authors: | , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2020
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| In: |
Clinics and research in hepatology and gastroenterology
Year: 2019, Volume: 44, Issue: 1, Pages: 38-48 |
| ISSN: | 2210-741X |
| DOI: | 10.1016/j.clinre.2019.05.005 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.clinre.2019.05.005 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S2210740119301020 
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| Author Notes: | Conrad Rauber, Miriam Awad, Ronald Koschny, Peter Sauer, Arianeb Mehrabi, Philip Gath, Karl-Heinz Weiss, Daniel Nils Gotthardt, Christian Rupp |
| Summary: | Background - After liver transplantation (LT), biliary complications are associated with reduced graft survival. We tested inflammation markers for their association with biliary damage and graft loss in bile. - Material and methods - The study design was a retrospective case-control study. Calprotectin, lactoferrin and pyruvate kinase were measured in endoscopically retrieved bile with ELISA. - Results - Calprotectin and lactoferrin were significantly higher in bile of ischemic-type biliary lesions and donor duct non-anastomotic strictures than in control, bile leakage, Cytomegalovirus infection, anastomotic stricture or acute cellular rejection patients (p<0.001) independent of serum liver values at endoscopy. Calprotectin (p=0.02) was independently associated with retransplantation free survival in multivariate analysis, as was γGT (p=0.03) but not ERC radiographic classification of the bile duct or cold ischemia time. - Conclusion - Calprotectin and lactoferrin are bile markers for biliary damage and are associated with re-transplantation free survival. They can differentiate progressive biliary damage from non-biliary liver value alterations after LT. |
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| Item Description: | Online 11 June 2019 Gesehen am 11.05.2020 |
| Physical Description: | Online Resource |
| ISSN: | 2210-741X |
| DOI: | 10.1016/j.clinre.2019.05.005 |