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The interchromatin compartment participates in the structural and functional organization of the cell nucleus

This article focuses on the role of the interchromatin compartment (IC) in shaping nuclear landscapes. The IC is connected with nuclear pore complexes (NPCs) and harbors splicing speckles and nuclear bodies. It is postulated that the IC provides routes for imported transcription factors to target si...

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Bibliographic Details
Main Authors: Cremer, Thomas (Author) , Cremer, Marion (Author) , Hübner, Barbara (Author) , Silahtaroglu, Asli (Author) , Hendzel, Michael (Author) , Lanctôt, Christian (Author) , Strickfaden, Hilmar (Author) , Cremer, Christoph (Author)
Format: Article (Journal)
Language:English
Published: 22 January 2020
In: Bioessays
Year: 2020, Volume: 42, Issue: 2
ISSN:1521-1878
DOI:10.1002/bies.201900132
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/bies.201900132
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/bies.201900132
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Author Notes:Thomas Cremer, Marion Cremer, Barbara Hübner, Asli Silahtaroglu, Michael Hendzel, Christian Lanctôt, Hilmar Strickfaden, Christoph Cremer
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Summary:This article focuses on the role of the interchromatin compartment (IC) in shaping nuclear landscapes. The IC is connected with nuclear pore complexes (NPCs) and harbors splicing speckles and nuclear bodies. It is postulated that the IC provides routes for imported transcription factors to target sites, for export routes of mRNA as ribonucleoproteins toward NPCs, as well as for the intranuclear passage of regulatory RNAs from sites of transcription to remote functional sites (IC hypothesis). IC channels are lined by less-compacted euchromatin, called the perichromatin region (PR). The PR and IC together form the active nuclear compartment (ANC). The ANC is co-aligned with the inactive nuclear compartment (INC), comprising more compacted heterochromatin. It is postulated that the INC is accessible for individual transcription factors, but inaccessible for larger macromolecular aggregates (limited accessibility hypothesis). This functional nuclear organization depends on still unexplored movements of genes and regulatory sequences between the two compartments.
Item Description:Gesehen am 12.05.2020
Physical Description:Online Resource
ISSN:1521-1878
DOI:10.1002/bies.201900132

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