Cover Image

The endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFR

Stimulation of cells with epidermal growth factor (EGF) induces internalization and partial degradation of the EGF receptor (EGFR) by the endo-lysosomal pathway. For continuous cell functioning, EGFR plasma membrane levels are maintained by transporting newly synthesized EGFRs to the cell surface. T...

Full description

Saved in:
Bibliographic Details
Main Authors: Scharaw, Sandra (Author) , Iskar, Murat (Author) , Ori, Alessandro (Author) , Boncompain, Gaelle (Author) , Laketa, Vibor (Author) , Poser, Ina (Author) , Lundberg, Emma (Author) , Perez, Franck (Author) , Beck, Martin (Author) , Bork, Peer (Author) , Pepperkok, Rainer (Author)
Format: Article (Journal)
Language:English
Published: November 08 2016
In: The journal of cell biology
Year: 2016, Volume: 215, Issue: 4, Pages: 543-558
ISSN:1540-8140
DOI:10.1083/jcb.201601090
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1083/jcb.201601090
Verlag, lizenzpflichtig, Volltext: https://rupress.org/jcb/article/215/4/543/38800/The-endosomal-transcriptional-regulator-RNF11
Get full text
Author Notes:Sandra Scharaw, Murat Iskar, Alessandro Ori, Gaelle Boncompain, Vibor Laketa, Ina Poser, Emma Lundberg, Franck Perez, Martin Beck, Peer Bork, and Rainer Pepperkok
Description
Summary:Stimulation of cells with epidermal growth factor (EGF) induces internalization and partial degradation of the EGF receptor (EGFR) by the endo-lysosomal pathway. For continuous cell functioning, EGFR plasma membrane levels are maintained by transporting newly synthesized EGFRs to the cell surface. The regulation of this process is largely unknown. In this study, we find that EGF stimulation specifically increases the transport efficiency of newly synthesized EGFRs from the endoplasmic reticulum to the plasma membrane.
Item Description:Gesehen am 13.05.2020
Physical Description:Online Resource
ISSN:1540-8140
DOI:10.1083/jcb.201601090

Similar Items