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Helix 8 is the essential structural motif of mechanosensitive GPCRs

GPCRs are versatile cellular sensors for chemical stimuli but the molecular mechanisms underlying mechanically induced GPCR activation have remained elusive. Here authors identify the C-terminal helix 8 (H8) as the essential structural motif endowing H1R and other GPCRs with mechanosensitivity.

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Bibliographic Details
Main Authors: Erdogmus, Serap (Author) , Storch, Ursula (Author) , Danner, Laura (Author) , Becker, Jasmin (Author) , Winter, Michaela Maria (Author) , Ziegler, Nicole (Author) , Wirth, Angela (Author) , Offermanns, Stefan (Author) , Hoffmann, Carsten (Author) , Gudermann, Thomas (Author) , Schnitzler, Michael (Author)
Format: Article (Journal)
Language:English
Published: 19 December 2019
In: Nature Communications
Year: 2019, Volume: 10
ISSN:2041-1723
DOI:10.1038/s41467-019-13722-0
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41467-019-13722-0
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41467-019-13722-0
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Author Notes:Serap Erdogmus, Ursula Storch, Laura Danner, Jasmin Becker, Michaela Winter, Nicole Ziegler, Angela Wirth, Stefan Offermanns, Carsten Hoffmann, Thomas Gudermann, Michael Mederos y Schnitzler
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Summary:GPCRs are versatile cellular sensors for chemical stimuli but the molecular mechanisms underlying mechanically induced GPCR activation have remained elusive. Here authors identify the C-terminal helix 8 (H8) as the essential structural motif endowing H1R and other GPCRs with mechanosensitivity.
Item Description:Gesehen am 13.05.2020
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-019-13722-0

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