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Selective binding and lateral clustering of α5β1 and αvβ3 integrins: unraveling the spatial requirements for cell spreading and focal adhesion assembly

Coordination of the specific functions of α5β1 and αvβ3 integrins is crucial for the precise regulation of cell adhesion, spreading and migration, yet the contribution of differential integrin-specific crosstalk to these processes remains unclear. To determine the specific functions of αvβ3 and α5β1...

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Hauptverfasser: Schaufler, Viktoria (VerfasserIn) , Czichos-Medda, Helmi (VerfasserIn) , Hirschfeld-Warneken, Vera C. (VerfasserIn) , Neubauer, Stefanie (VerfasserIn) , Rechenmacher, Florian (VerfasserIn) , Medda, Rebecca (VerfasserIn) , Kessler, Horst (VerfasserIn) , Geiger, Benjamin (VerfasserIn) , Spatz, Joachim P. (VerfasserIn) , Cavalcanti-Adam, Elisabetta A. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 29 Apr 2016
In: Cell adhesion & migration
Year: 2016, Jahrgang: 10, Heft: 5, Pages: 505-515
ISSN:1933-6926
DOI:10.1080/19336918.2016.1163453
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1080/19336918.2016.1163453
Verlag, lizenzpflichtig, Volltext: https://www.tandfonline.com/doi/full/10.1080/19336918.2016.1163453
Volltext
Verfasserangaben:Viktoria Schaufler, Helmi Czichos-Medda, Vera Hirschfeld-Warnecken, Stefanie Neubauer, Florian Rechenmacher, Rebecca Medda, Horst Kessler, Benjamin Geiger, Joachim P. Spatz & E. Ada Cavalcanti-Adam
Beschreibung
Zusammenfassung:Coordination of the specific functions of α5β1 and αvβ3 integrins is crucial for the precise regulation of cell adhesion, spreading and migration, yet the contribution of differential integrin-specific crosstalk to these processes remains unclear. To determine the specific functions of αvβ3 and α5β1 integrins, we used nanoarrays of gold particles presenting immobilized, integrin-selective peptidomimetic ligands.
Beschreibung:Gesehen am 13.05.2020
Beschreibung:Online Resource
ISSN:1933-6926
DOI:10.1080/19336918.2016.1163453

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