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Low-grade epilepsy-associated neuroepithelial tumours - the 2016 WHO classification

The recently revised 5th edition of the WHO classification of brain tumours 'blue book' will have a major impact in stratifying diagnosis and treatment. However, low-grade neuroepithelial tumours (LEATs), which present with early-onset focal epilepsy, lack integrated clinicopathological an...

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Main Authors: Blümcke, Ingmar (Author) , Aronica, Eleonora (Author) , Becker, Albert (Author) , Capper, David (Author) , Coras, Roland (Author) , Honavar, Mrinalini (Author) , Jacques, Thomas S. (Author) , Kobow, Katja (Author) , Miyata, Hajime (Author) , Mühlebner, Angelika (Author) , Pimentel, José (Author) , Söylemezoğlu, Figen (Author) , Thom, Maria (Author)
Format: Article (Journal)
Language:English
Published: 18 November 2016
In: Nature reviews. Neurology
Year: 2016, Volume: 12, Issue: 12, Pages: 732-740
ISSN:1759-4766
DOI:10.1038/nrneurol.2016.173
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nrneurol.2016.173
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nrneurol.2016.173
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Author Notes:Ingmar Blümcke, Eleonora Aronica, Albert Becker, David Capper, Roland Coras, Mrinalini Honavar, Thomas S. Jacques, Katja Kobow, Hajime Miyata, Angelika Mühlebner, José Pimentel, Figen Söylemezoğlu, Maria Thom
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Summary:The recently revised 5th edition of the WHO classification of brain tumours 'blue book' will have a major impact in stratifying diagnosis and treatment. However, low-grade neuroepithelial tumours (LEATs), which present with early-onset focal epilepsy, lack integrated clinicopathological and molecular genetic diagnostic tools. The Neuropathology Task Force of the International League against Epilepsy will critically discuss this issue, as well as offer perspectives on how to decipher and validate clinically meaningful LEAT entities using the current WHO approach.
Item Description:Gesehen am 13.05.2020
Physical Description:Online Resource
ISSN:1759-4766
DOI:10.1038/nrneurol.2016.173

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