Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells

Genetic and epigenetic abnormalities have been found to result from reprogramming of differentiated cells into human induced pluripotent stem cells (hiPSCs). Here, Klawitter et al.identify endogenous L1, Alu and SVA mobilization during reprogramming, highlighting the risk of insertional mutagens in...

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Main Authors:	Jung-Klawitter, Sabine (Author) , Fuchs, Nina V. (Author) , Upton, Kyle R. (Author) , Muñoz-Lopez, Martin (Author) , Shukla, Ruchi (Author) , Wang, Jichang (Author) , Garcia-Cañadas, Marta (Author) , Lopez-Ruiz, Cesar (Author) , Gerhardt, Daniel J. (Author) , Sebe, Attila (Author) , Grabundzija, Ivana (Author) , Merkert, Sylvia (Author) , Gerdes, Patricia (Author) , Pulgarin, J. Andres (Author) , Bock, Anja (Author) , Held, Ulrike (Author) , Witthuhn, Anett (Author) , Haase, Alexandra (Author) , Sarkadi, Balázs (Author) , Löwer, Johannes (Author) , Wolvetang, Ernst J. (Author) , Martin, Ulrich (Author) , Ivics, Zoltán (Author) , Izsvák, Zsuzsanna (Author) , Garcia-Perez, Jose L. (Author) , Faulkner, Geoffrey J. (Author) , Schumann, Gerald G. (Author)
Format:	Article (Journal)
Language:	English
Published:	8 Jan 2016
In:	Nature Communications Year: 2016, Volume: 7, Pages: 1-14
ISSN:	2041-1723
DOI:	10.1038/ncomms10286
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/ncomms10286 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/ncomms10286
Author Notes:	Sabine Klawitter, Nina V. Fuchs, Kyle R. Upton, Martin Muñoz-Lopez, Ruchi Shukla, Jichang Wang, Marta Garcia-Cañadas, Cesar Lopez-Ruiz, Daniel J. Gerhardt, Attila Sebe, Ivana Grabundzija, Sylvia Merkert, Patricia Gerdes, J. Andres Pulgarin, Anja Bock, Ulrike Held, Anett Witthuhn, Alexandra Haase, Balázs Sarkadi, Johannes Löwer, Ernst J. Wolvetang, Ulrich Martin, Zoltán Ivics, Zsuzsanna Izsvák, Jose L. Garcia-Perez, Geoffrey J. Faulkner & Gerald G. Schumann