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Multicenter Evaluation of a Novel Automated Rapid Detection System of BRAF Status in Formalin-Fixed, Paraffin-Embedded Tissues

The mutated BRAF oncogene represents a therapeutic target in malignant melanoma. Because BRAF mutations are also involved in the pathogenesis of other human malignancies, the use of specific BRAF inhibitors might also be extended to other diseases in the future. A prerequisite for the clinical appli...

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Main Authors: Schiefer, Ana-Iris (Author) , Parlow, Laura (Author) , Gabler, Lisa (Author) , Mesteri, Ildiko (Author) , Koperek, Oskar (Author) , Deimling, Andreas von (Author) , Streubel, Berthold (Author) , Preusser, Matthias (Author) , Lehmann, Annika (Author) , Kellner, Udo (Author) , Pauwels, Patrick (Author) , Lambin, Suzan (Author) , Dietel, Manfred (Author) , Hummel, Michael (Author) , Klauschen, Frederick (Author) , Birner, Peter (Author) , Möbs, Markus (Author)
Format: Article (Journal)
Language:English
Published: 24 February 2016
In: The journal of molecular diagnostics
Year: 2016, Volume: 18, Issue: 3, Pages: 370-377
ISSN:1943-7811
DOI:10.1016/j.jmoldx.2015.12.005
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jmoldx.2015.12.005
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1525157816000507
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Author Notes:Ana-Iris Schiefer, Laura Parlow, Lisa Gabler, Ildiko Mesteri, Oskar Koperek, Andreas von Deimling, Berthold Streubel, Matthias Preusser, Annika Lehmann, Udo Kellner, Patrick Pauwels, Suzan Lambin, Manfred Dietel, Michael Hummel, Frederick Klauschen, Peter Birner, and Markus Möbs
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Summary:The mutated BRAF oncogene represents a therapeutic target in malignant melanoma. Because BRAF mutations are also involved in the pathogenesis of other human malignancies, the use of specific BRAF inhibitors might also be extended to other diseases in the future. A prerequisite for the clinical application of BRAF inhibitors is the reliable detection of activating BRAF mutations in routine histopathological samples. In a multicenter approach, we evaluated a novel and fully automated PCR-based system (Idylla) capable of detecting BRAF V600 mutations in formalin-fixed, paraffin-embedded tissue within 90 minutes with high sensitivity.
Item Description:Gesehen am 13.05.2020
Physical Description:Online Resource
ISSN:1943-7811
DOI:10.1016/j.jmoldx.2015.12.005

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