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The Gq signalling pathway inhibits brown and beige adipose tissue

Brown and beige adipose tissues contribute to organismal energy expenditure by generating heat. Here, Klepac et al. survey G protein-coupled receptors in brown fat and show that Gq-coupled receptors inhibit expression of thermogenic proteins in mice and in human adipocytes.

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Bibliographic Details
Main Authors: Klepac, Katarina (Author) , Kilić, Ana (Author) , Gnad, Thorsten (Author) , Brown, Loren M. (Author) , Herrmann, Beate (Author) , Wilderman, Andrea (Author) , Balkow, Aileen (Author) , Glöde, Anja (Author) , Simon, Katharina (Author) , Lidell, Martin E. (Author) , Betz, Matthias J. (Author) , Enerbäck, Sven (Author) , Wess, Jürgen (Author) , Freichel, Marc (Author) , Blüher, Matthias (Author) , König, Gabi (Author) , Kostenis, Evi (Author) , Insel, Paul A. (Author) , Pfeifer, Alexander (Author)
Format: Article (Journal)
Language:English
Published: 9 Mar 2016
In: Nature Communications
Year: 2016, Volume: 7, Pages: 1-10
ISSN:2041-1723
DOI:10.1038/ncomms10895
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/ncomms10895
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/ncomms10895
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Author Notes:Katarina Klepac, Ana Kilić, Thorsten Gnad, Loren M. Brown, Beate Herrmann, Andrea Wilderman, Aileen Balkow, Anja Glöde, Katharina Simon, Martin E. Lidell, Matthias J. Betz, Sven Enerbäck, Jürgen Wess, Marc Freichel, Matthias Blüher, Gabi König, Evi Kostenis, Paul A. Insel, Alexander Pfeifer
Description
Summary:Brown and beige adipose tissues contribute to organismal energy expenditure by generating heat. Here, Klepac et al. survey G protein-coupled receptors in brown fat and show that Gq-coupled receptors inhibit expression of thermogenic proteins in mice and in human adipocytes.
Item Description:Im Titel ist der Buchstabe "q" in Gq tiefgestellt
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Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/ncomms10895

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