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DNA methylation-based profiling of uterine neoplasms: a novel tool to improve gynecologic cancer diagnostics

Uterine neoplasms comprise a broad spectrum of lesions, some of which may pose a diagnostic challenge even to experienced pathologists. Recently, genome-wide DNA methylation-based classification of central nervous system tumors has been shown to increase diagnostic precision in clinical practice whe...

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Main Authors: Kommoss, Felix (Author) , Stichel, Damian (Author) , Schrimpf, Daniel (Author) , Kriegsmann, Mark (Author) , Tessier-Cloutier, Basile (Author) , Talhouk, Aline (Author) , McAlpine, Jessica N. (Author) , Chang, Kenneth T. E. (Author) , Sturm, Dominik (Author) , Pfister, Stefan (Author) , Romero-Pérez, Laura (Author) , Kirchner, Thomas (Author) , Grünewald, Thomas G. P. (Author) , Buslei, Rolf (Author) , Sinn, Peter (Author) , Mechtersheimer, Gunhild (Author) , Schirmacher, Peter (Author) , Schmidt, Dietmar (Author) , Lehr, Hans-Anton (Author) , Sahm, Felix (Author) , Huntsman, David G. (Author) , Gilks, C. Blake (Author) , Kommoss, Friedrich (Author) , Deimling, Andreas von (Author) , Kölsche, Christian (Author)
Format: Article (Journal)
Language:English
Published: 2020
In: Journal of cancer research and clinical oncology
Year: 2020, Volume: 146, Issue: 1, Pages: 97-104
ISSN:1432-1335
DOI:10.1007/s00432-019-03093-w
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00432-019-03093-w
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Author Notes:Felix K. F. Kommoss, Damian Stichel, Daniel Schrimpf, Mark Kriegsmann, Basile Tessier-Cloutier, Aline Talhouk, Jessica N. McAlpine, Kenneth T. E. Chang, Dominik Sturm, Stefan M. Pfister, Laura Romero-Pérez, Thomas Kirchner, Thomas G. P. Grünewald, Rolf Buslei, Hans-Peter Sinn, Gunhild Mechtersheimer, Peter Schirmacher, Dietmar Schmidt, Hans-Anton Lehr, Felix Sahm, David G. Huntsman, C. Blake Gilks, Friedrich Kommoss, Andreas von Deimling, Christian Koelsche
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Summary:Uterine neoplasms comprise a broad spectrum of lesions, some of which may pose a diagnostic challenge even to experienced pathologists. Recently, genome-wide DNA methylation-based classification of central nervous system tumors has been shown to increase diagnostic precision in clinical practice when combined with standard histopathology. In this study, we describe DNA methylation patterns of a diverse set of uterine neoplasms and test the applicability of array-based DNA methylation profiling.
Item Description:Published: 25 November 2019
Gesehen am 14.05.2020
Physical Description:Online Resource
ISSN:1432-1335
DOI:10.1007/s00432-019-03093-w

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