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Minichromosome maintenance expression defines slow-growing gastroenteropancreatic neuroendocrine neoplasms

Small intestinal neuroendocrine neoplasm (SI-NEN) proliferation is quantified by Ki67 measurements which capture G1-G2M phases of the cell cycle. G0 and early G1 phases, typical of slow-growing cells, can be detected by minichromosome maintenance protein (MCM) expression. We hypothesized that these...

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Bibliographic Details
Main Authors: Schimmack, Simon (Author) , Lawrence, Ben (Author) , Kenney, Barton (Author) , Schmitz-Winnenthal, Friedrich Hubertus (Author) , Modlin, Irvin M. (Author) , Kidd, Mark (Author)
Format: Article (Journal)
Language:English
Published: 14 October 2016
In: Translational oncology
Year: 2016, Volume: 9, Issue: 5, Pages: 411-418
ISSN:1936-5233
DOI:10.1016/j.tranon.2016.07.006
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tranon.2016.07.006
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1936523316300626
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Author Notes:Simon Schimmack, Ben Lawrence, Barton Kenney, Hubertus Schmitz-Winnenthal, Irvin M. Modlin and Mark Kidd
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Summary:Small intestinal neuroendocrine neoplasm (SI-NEN) proliferation is quantified by Ki67 measurements which capture G1-G2M phases of the cell cycle. G0 and early G1 phases, typical of slow-growing cells, can be detected by minichromosome maintenance protein (MCM) expression. We hypothesized that these replication licensing markers may provide clinically relevant information to augment Ki67 in low-grade neuroendocrine neoplasia.
Item Description:Gesehen am 14.05.2020
Physical Description:Online Resource
ISSN:1936-5233
DOI:10.1016/j.tranon.2016.07.006

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