Relevance of Sp binding site polymorphism in WWOX for treatment outcome in pancreatic cancer
A genome-wide association study (GWAS) suggested inherited genetic single-nucleotide polymorphisms (SNPs) affecting overall survival (OS) in advanced pancreatic cancer. To identify robust clinical biomarkers, we tested the strongest reported candidate loci in an independent patient cohort, assessed...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 8, 2016
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| In: |
Journal of the National Cancer Institute
Year: 2016, Jahrgang: 108, Heft: 5 |
| ISSN: | 1460-2105 |
| DOI: | 10.1093/jnci/djv387 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1093/jnci/djv387 Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/jnci/article/108/5/djv387/2412583 |
| Verfasserangaben: | Markus A. Schirmer, Claudia M. Lüske, Sebastian Roppel, Alexander Schaudinn, Christian Zimmer, Ruben Pflüger, Martin Haubrock, Jacobe Rapp, Cenap Güngör, Maximilian Bockhorn, Thilo Hackert, Thomas Hank, Oliver Strobel, Jens Werner, Jakob R. Izbicki, Steven A. Johnsen, Jochen Gaedcke, Jürgen Brockmöller, B. Michael Ghadimi |
| Zusammenfassung: | A genome-wide association study (GWAS) suggested inherited genetic single-nucleotide polymorphisms (SNPs) affecting overall survival (OS) in advanced pancreatic cancer. To identify robust clinical biomarkers, we tested the strongest reported candidate loci in an independent patient cohort, assessed cellular drug sensitivity, and evaluated molecular effects. |
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| Beschreibung: | Gesehen am 14.05.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 1460-2105 |
| DOI: | 10.1093/jnci/djv387 |