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MFAP4 promotes vascular smooth muscle migration, proliferation and accelerates neointima formation

Arterial injury stimulates remodeling responses that, when excessive, lead to stenosis. These responses are influenced by integrin signaling in vascular smooth muscle cells (VSMCs). Microfibrillar-associated protein 4 (MFAP4) is an integrin ligand localized to extracellular matrix fibers in the vasc...

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Main Authors: Schlosser, Anders (Author) , Pilecki, Bartosz (Author) , Hemstra, Line E. (Author) , Kejling, Karin (Author) , Kristmannsdottir, Gudlaug B. (Author) , Wulf-Johansson, Helle (Author) , Moeller, Jesper B. (Author) , Füchtbauer, Ernst-Martin (Author) , Nielsen, Ole (Author) , Kirketerp-Møller, Katrine (Author) , Dubey, Lalit K. (Author) , Hansen, Pernille B.L. (Author) , Stubbe, Jane (Author) , Wrede, Christoph (Author) , Hegermann, Jan (Author) , Ochs, Matthias (Author) , Rathkolb, Birgit (Author) , Schrewe, Anja (Author) , Bekeredjian, Raffi (Author) , Wolf, Eckhard (Author) , Gailus-Durner, Valérie (Author) , Fuchs, Helmut (Author) , Hrabě de Angelis, Martin (Author) , Lindholt, Jes S. (Author) , Holmskov, Uffe (Author) , Sorensen, Grith L. (Author)
Format: Article (Journal)
Language:English
Published: 2016
In: Arteriosclerosis, thrombosis, and vascular biology
Year: 2016, Volume: 36, Issue: 1, Pages: 122-133
ISSN:1524-4636
DOI:10.1161/ATVBAHA.115.306672
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1161/ATVBAHA.115.306672
Verlag, lizenzpflichtig, Volltext: https://www.ahajournals.org/doi/10.1161/ATVBAHA.115.306672
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Author Notes:Anders Schlosser, Bartosz Pilecki, Line E. Hemstra, Karin Kejling, Gudlaug B. Kristmannsdottir, Helle Wulf-Johansson, Jesper B. Moeller, Ernst-Martin Füchtbauer, Ole Nielsen, Katrine Kirketerp-Møller, Lalit K. Dubey, Pernille B.L. Hansen, Jane Stubbe, Christoph Wrede, Jan Hegermann, Matthias Ochs, Birgit Rathkolb, Anja Schrewe, Raffi Bekeredjian, Eckhard Wolf, Valérie Gailus-Durner, Helmut Fuchs, Martin Hrabě de Angelis, Jes S. Lindholt, Uffe Holmskov, Grith L. Sorensen

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520 |a Arterial injury stimulates remodeling responses that, when excessive, lead to stenosis. These responses are influenced by integrin signaling in vascular smooth muscle cells (VSMCs). Microfibrillar-associated protein 4 (MFAP4) is an integrin ligand localized to extracellular matrix fibers in the vascular wall. The role of MFAP4 in vascular biology is unknown. We aimed to test the hypothesis that MFAP4 would enhance integrin-dependent VSMC activation. 
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