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Lessons learned: resolving the enigma of genetic factors in IBS

The pathophysiology of IBS is multifactorial with a substantial genetic component. Although a variety of genetic and epigenetic changes have been associated with different IBS subtypes, reproducible validation of these results is still outstanding and pharmacogenetic strategies have yet to be devise...

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Main Authors: Gazouli, Maria (Author) , Wouters, Mira M. (Author) , Kapur-Pojskić, Lejla (Author) , Bengtson, May-Bente (Author) , Friedman, Eitan (Author) , Nikčević, Gordana (Author) , Demetriou, Christiana A. (Author) , Mulak, Agata (Author) , Santos, Javier (Author) , Niesler, Beate (Author)
Format: Article (Journal)
Language:English
Published: 04 January 2016
In: Nature reviews. Gastroenterology & hepatology
Year: 2016, Volume: 13, Issue: 2, Pages: 77-87
ISSN:1759-5053
DOI:10.1038/nrgastro.2015.206
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nrgastro.2015.206
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nrgastro.2015.206
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Author Notes:Maria Gazouli, Mira M. Wouters, Lejla Kapur-Pojskić, May-Bente Bengtson, Eitan Friedman, Gordana Nikčević, Christiana A. Demetriou, Agata Mulak, Javier Santos and Beate Niesler
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Summary:The pathophysiology of IBS is multifactorial with a substantial genetic component. Although a variety of genetic and epigenetic changes have been associated with different IBS subtypes, reproducible validation of these results is still outstanding and pharmacogenetic strategies have yet to be devised. Here, the COST Action BM1106 GENIEUR (epi)genetic working group gives insights into the situation to date, advances and challenges that still need addressing.
Item Description:Gesehen am 15.05.2020
Physical Description:Online Resource
ISSN:1759-5053
DOI:10.1038/nrgastro.2015.206

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